|
Factors
|
ADAM10 expression
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
Low (mean ± SE)
|
High (mean ± SE)
|
p-value
|
OR (95%CI)
|
p-value
|
OR (95%CI)
|
p-value
|
|---|
|
Age at diagnosis (years)
|
|
< 55
|
34 (120.4 ± 54.60)
|
15 (252.0 ± 34.58)
|
0.008**
|
0.35 (0.12–1.00)
|
0.050
|
0.96 (0.19–4.77)
|
0.963
|
|
≥ 55
|
39 (91.2 ± 62.02)
|
6 (297.5 ± 6.12)
| | | | | |
|
Menopause
|
|
Yes
|
53 (98.9 ± 62.35)
|
10 (277.5 ± 27.61)
|
0.024*
|
0.34 (0.13–0.93)
|
0.036*
|
0.45 (0.05–0.53)
|
0.292
|
|
No
|
20 (120.5 ± 51.9)
|
11 (253.6 ± 39.94)
| | | | | |
|
BMI (kg/m2)
|
|
> 23
|
51 (106.7 ± 56.50)
|
6 (245.0 ± 37.55)
|
0.023*
|
5.80 (1.99–16.91)
|
0.001**
|
0.17 (0.10–2.00)
|
0.002**
|
|
≤ 23
|
22 (100.5 ± 68.97)
|
15 (273.0 ± 33.16)
| | | | | |
|
Histological grade
|
|
I
|
4 (95.0 ± 72.23)
|
2 (262.5 ± 53.03)
|
0.172
|
0.55 (0.18–1.65)
|
0.286
| | |
|
II
|
56 (98.4 ± 59.23)
|
17 (270.0 ± 34.37)
| | | | | |
|
III
|
13 (135.4 ± 55.28)
|
2 (225.0 ± 21.21)
| | | | | |
|
Tumor size
|
|
T1
|
4 (78.8 ± 55.43)
|
2 (262.5 ± 53.03)
|
0.683
|
0.89 (0.29–2.76)
|
0.846
| | |
|
T2
|
60 (104.8 ± 62.52)
|
16 (266.3 ± 37.35)
| | | | | |
|
T3
|
9 (116.1 ± 45.26)
|
3 (260.0 ± 31.22)
| | | | | |
|
Distant metastasis (before NACT)
|
|
Yes
|
4 (107.5 ± 70.77)
|
3 (300)
|
0.287
|
0.56 (0.06–4.92)
|
0.599
| | |
|
No
|
53 (109.7 ± 63.91)
|
16 (282.2 ± 21.37)
| | | | | |
|
Regional lymphatic metastasis (after NACT)
|
|
Yes
|
38 (103.3 ± 62.63)
|
9 (283.3 ± 21.79)
|
0.066
|
1.42 (0.52–3.83)
|
0.492
| | |
|
No
|
19 (122.1 ± 65.77)
|
10 (286.5 ± 20.55)
| | | | | |
|
Response to NACT
|
|
Good
|
58 (99.5 ± 59.41)
|
11 (285 ± 27.66)
|
0.023*
|
0.28 (0.10–0.79)
|
0.016*
|
0.29 (0.44–16.22)
|
0.042*
|
|
Poor
|
15 (125.3 ± 60.34)
|
10 (243.0 ± 31.46)
| | | | | |
- OR odds ratio, CI confidence interval
- *p < 0.05, **p < 0.01
