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Table 3 Correlation between different responses to NACT and clinic pathological factors in 94 breast cancer tissues

From: ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc

Factors Response to NACT Univariate analysis Multivariate analysis
Poor Good p-value OR (95%CI) p-value OR (95%CI) p-value
ADAM10 expression level (pre-NACT)
Low 15 58 0.013* 0.28 (0.10–0.79) 0.016* 0.25 (0.07–0.86) 0.028*
High 10 11      
ADAM10 expression level (post-NACT)
Low 21 36 0.266 2.19 (0.64–7.46) 0.211   
High 4 15      
Age at diagnosis (years)
 < 55 19 30 0.009** 4.12 (1.46–11.58) 0.007** 3.85 (0.99–14.92) 0.051
 ≥ 55 6 39      
Menopause
Yes 13 50 0.055 2.43 (0.94–6.26) 0.066   
No 12 19      
BMI (kg/m2)
 > 23 14 43  < 0.001** 0.77 (0.30–1.95) 0.580   
 ≤ 23 26 11      
Histological grade
I 3 3 0.059 0.67 (0.25–1.79) 0.420   
II 15 58      
III 7 8      
Tumor size
T1 2 4 0.772 0.89 (0.31–2.55) 0.827   
T2 19 57      
T3 4 8      
Distant metastasis (before NACT)
Yes 2 5 1.000 0.90 (0.16–4.96) 0.902   
No 23 64      
Regional lymphatic metastasis (after NACT)
Yes 10 32 0.644 0.77 (0.30–1.95) 0.583   
No 15 37      
  1. OR odds ratio, CI confidence interval
  2. *p < 0.05, **p < 0.01
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Cancer Cell International

ISSN: 1475-2867

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