|
Factors
|
Response to NACT
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
Poor
|
Good
|
p-value
|
OR (95%CI)
|
p-value
|
OR (95%CI)
|
p-value
|
|---|
|
ADAM10 expression level (pre-NACT)
|
|
Low
|
15
|
58
|
0.013*
|
0.28 (0.10–0.79)
|
0.016*
|
0.25 (0.07–0.86)
|
0.028*
|
|
High
|
10
|
11
| | | | | |
|
ADAM10 expression level (post-NACT)
|
|
Low
|
21
|
36
|
0.266
|
2.19 (0.64–7.46)
|
0.211
| | |
|
High
|
4
|
15
| | | | | |
|
Age at diagnosis (years)
|
|
< 55
|
19
|
30
|
0.009**
|
4.12 (1.46–11.58)
|
0.007**
|
3.85 (0.99–14.92)
|
0.051
|
|
≥ 55
|
6
|
39
| | | | | |
|
Menopause
|
|
Yes
|
13
|
50
|
0.055
|
2.43 (0.94–6.26)
|
0.066
| | |
|
No
|
12
|
19
| | | | | |
|
BMI (kg/m2)
|
|
> 23
|
14
|
43
|
< 0.001**
|
0.77 (0.30–1.95)
|
0.580
| | |
|
≤ 23
|
26
|
11
| | | | | |
|
Histological grade
|
|
I
|
3
|
3
|
0.059
|
0.67 (0.25–1.79)
|
0.420
| | |
|
II
|
15
|
58
| | | | | |
|
III
|
7
|
8
| | | | | |
|
Tumor size
|
|
T1
|
2
|
4
|
0.772
|
0.89 (0.31–2.55)
|
0.827
| | |
|
T2
|
19
|
57
| | | | | |
|
T3
|
4
|
8
| | | | | |
|
Distant metastasis (before NACT)
|
|
Yes
|
2
|
5
|
1.000
|
0.90 (0.16–4.96)
|
0.902
| | |
|
No
|
23
|
64
| | | | | |
|
Regional lymphatic metastasis (after NACT)
|
|
Yes
|
10
|
32
|
0.644
|
0.77 (0.30–1.95)
|
0.583
| | |
|
No
|
15
|
37
| | | | | |
- OR odds ratio, CI confidence interval
- *p < 0.05, **p < 0.01
