BKM120 (μM)
|
PQR309 (μM)
|
URMC-099 (μM)
|
CI* in U-251 MG cells
|
CI in U-343 MG cells
|
---|
BKM120 + URMC-099
|
PQR309 + URMC-099
|
BKM120 + URMC-099
|
PQR309 + URMC-099
|
---|
0.5
|
1
|
0.75
|
1.3989 ± 0.2163
|
1.5254 ± 0.3801
|
4.7114 ± 0.2524
|
1.1346 ± 0.0512
|
1
|
2
|
1.5
|
1.4334 ± 0.1484
|
1.4664 ± 0.2958
|
3.6418 ± 0.8218
|
1.9790 ± 0.0174
|
2
|
4
|
3
|
1.1565 ± 0.2646
|
0.8072 ± 0.0409
|
2.9486 ± 0.6378
|
1.7963 ± 0.2530
|
3
|
6
|
4.5
|
0.8357 ± 0.0579
|
0.6518 ± 0.0092
|
1.2952 ± 0.5308
|
0.8334 ± 0.1518
|
4
|
8
|
6
|
1.1241 ± 0.1438
|
1.0504 ± 0.1408
|
0.9371 ± 0.0928
|
0.8804 ± 0.0166
|
5
|
10
|
7.5
|
1.6589 ± 0.2057
|
1.8739 ± 0.1506
|
1.1621 ± 0.0186
|
1.1876 ± 0.0811
|
- * Data were presented as mean ± S.E.M. CI < 0.9 indicates synergistic effects; CI > 1.1 indicates antagonistic effects; CI between 0.9 and 1.1 indicates additive effects