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Fig. 9 | Cancer Cell International

Fig. 9

From: Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis

Fig. 9

A schematic diagram for the functions and mechanism of linc00887 in regulation of cervical cancer. Linc00887 is downregulated in human cervical cancer cells in vitro, which sponges miR-454-3p and positively regulates expression of FRMD6 gene. FRMD6 is an identified regulator to phosphorylate MST1/2 and activate its downstream key kinases in Hippo signaling pathway LATS1/2 or TAZ, thus inhibiting cell proliferation and invasion

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