Fig. 5

Circ-CCDC66 mediates REXO1 expression to promote cervical cancer progression via miR-452-5p. Cell models were constructed by transfecting Sh-NC, Sh-circ-CCDC66, Sh-circ-CCDC66 + OE-NC, Sh-circ-CCDC66 + OE-REXO1 into Hela and SiHa cells. a transfection efficiencies were detected by qRT-PCR. b Cells were subjected to CCK-8 assays for cell proliferation detection. c and d Transwell migration assays were performed to evaluate cell migration abilities, number of migrated cells were recorded. e and f Cell invasion abilities were determined by transwell invasion assays, invasion cells were recorded and comparative statistics were presented. Data were presented as mean ± SD, all experiments were performed at least three times. Scare bar for Transwell image: 100 μm *P < 0.05, **P < 0.01