Fig. 5

CERK knockdown augments cytotoxicity of chemotherapeutic agents in TNBC cells. a Representative images of Boyden chamber assay showing migrated cells among the CERK-depleted MDA-MB-231 cell population in the absence and presence of paclitaxel or cisplatin. CERK depletion significantly augments the anti-migratory (b), anti-proliferative (c), and pro-apoptotic (d) effects of cisplatin and paclitaxel. Paclitaxel (at 100 nM) and cisplatin (at 1 µM) were added to the cell medium at 24 h post-transfection; *P < 0.05, compared with the chemotherapeutic agent alone