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Fig. 5 | Cancer Cell International

Fig. 5

From: CircNEIL3 promotes cervical cancer cell proliferation by adsorbing miR-137 and upregulating KLF12

Fig. 5

KLF12 was one of the direct target gene of miR-137. a TargetScan, miRDB and Pictar were used to predict the potential target genes of miR-137. b After upregulation of miR-137 expression in SiHa cell lines, the candidate mRNA expression was detected by qRT-PCR. c After downregulation of miR-137 expression in SiHa cell lines, the candidate mRNA expression was detected by qRT-PCR. d The expressions of KLF12 protein in SiHa and Hela transfected with miR-137 mimic or miR-137 inhibitor were measured by Western blotting. e MiR-137 and KLF12 binding sequences and KLF12 mutation sequences. f Luciferase activity in SiHa cells co-transfected with luciferase reporter containing wild-type or mutant KLF12 sequences and miR-137 mimic or control. Data were represented as means ± S.D. of at least three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

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