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Fig. 2 | Cancer Cell International

Fig. 2

From: Transcription elongation factor A-like 7, regulated by miR-758-3p inhibits the progression of melanoma through decreasing the expression levels of c-Myc and AKT1

Fig. 2

TCEAL7 inhibited melanoma cell proliferation, invasion and migration, and induced cell apoptosis. a–f RT-PCR and western blotting assays were used to detect the knockdown and overexpression efficiencies of TCEAL7 in A375 and WM-115 cell lines. g, h CCK-8 assay was used to test cell proliferation following TCEAL7 was overexpressed/silenced in WM-115 and A375 cells. i, j Transwell chamber assay was used to test cell invasion ability following TCEAL7 was overexpressed/silenced in WM-115 and A375 cells. k, l TCEAL7 effect on the apoptosis of WM-115 and A375 cells were detected by flow cytometry. m, n Starch assay was used to test cell migration ability following TCEAL7 was overexpressed/silenced in WM-115 and A375 cells. o, p Western blotting assay was used to measure the expression levels of E-cadherin, N-cadherin and PCNA following TCEAL7 was overexpressed/silenced in WM-115 and A375 cells. (*P < 0.05 and **P < 0.01, compared with Lenti-NC group; #P < 0.05, compared with si-Scramble group)

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Cancer Cell International

ISSN: 1475-2867

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