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Fig. 3 | Cancer Cell International

Fig. 3

From: Transcription elongation factor A-like 7, regulated by miR-758-3p inhibits the progression of melanoma through decreasing the expression levels of c-Myc and AKT1

Fig. 3

TCEAL7 increased the expression levels of AKT1, AKT2 and c-Myc in melanoma cells. a–d The mRNA and/or protein levels of AKT1, AKT2, p-AKT, c-Myc, STAT3, β-catenin, TGF-β, p-SMAD2, p-SMAD3, YAP and FOXO1 in Lenti-TCEAL7/si-TCEAL7-transfected WM-115 and A375 cells were determined by RT-PCR and western blotting assays. e–g Correlations between the expression levels of TCEAL7 and AKT1, AKT2 and c-Myc in melanoma samples were predicted by using the starBase database. h–j. Correlations between the expression levels of TCEAL7 and AKT1, AKT2 and c-Myc in 30 melanoma tissues samples were determined. (a and c *P < 0.05, compared with si-Scramble group; #P < 0.05, compared with Lenti-NC group; b and d, *P < 0.05, compared with Lenti-NC group; #P < 0.05, compared with si-Scramble group)

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Cancer Cell International

ISSN: 1475-2867

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