Fig. 5

The upregulation of EZH2 by lncRNA MALAT1 was antagonized by miR-124-3p. a The miR-124-3p binding site in EZH2 3’UTR predicted using TargetScan. b The expression levels of lncRNA MALAT1, miR-124-3p, and EZH2 after lncRNA MALAT1 and/or miR-124-3p overexpression were analyzed by quantitative real-time PCR. c The effects of lncRNA MALAT1 and miR-124-3p on EZH2 protein level were examined by western blot. Ctrl, Normal culture conditions. *p < 0.01 compared to control; ^#p < 0.01 compared to MALAT1; ^&p < 0.01 compared to 124-3p