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Fig.5 | Cancer Cell International

Fig.5

From: Suppression of TCAB1 expression induced cellular senescence by lessening proteasomal degradation of p21 in cancer cells

Fig.5

Overexpression of TCAB1 prevented senescence by regulating the expression of p21. a A549 cells stable expressed shRNA against TCAB1 were infected with LV-TCAB1 lentivirus and control lentivirus. Cellular senescence was measured by Senescence-associated (SA)-β-gal assay. b Quantification from A for SA-β-gal positive cells in percentages (n = 8). c Western blotting were used to determine TCAB1 and p21 expression. GAPDH was loading control. d RNAseq results of TCAB1, p21, p16 and p53 levels in lung adenocarcinoma patients of both p53 wild type (362 cases) and mutant p53 (152 cases) groups from cBioPortal (Luad_tcga_pan_can_atlas_2018) were summarized in 3D terrain charts

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Cancer Cell International

ISSN: 1475-2867

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