Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis

Zhao, Jiawen; Huang, Weijia; Wu, Yongxian; Luo, Yihuan; Wu, Bo; Cheng, Jiwen; Chen, Junqiang; Liu, Deyun; Li, Chengyang

doi:10.1186/s12935-020-1094-5

Table 1 Main characteristics of the included studies in the meta-analysis

From: Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis

First author	Year	Region	Disease site	Disease stage	Inclusion period	No. of patients	Age	Treatment	Analysis of survival	Cut off value (× 10⁹/L)	Study design	Follow-up (months)	Outcome reported	NOS score
Yang [19]	2018	China^A	Hypopharyngeal cancer	Non metastatic	2009–2014	197	NR	Chemo + Resection	Univariate	1.7	Retrospective	30.95^b	OS	8
Pang [20]	2018	China^A	Hepatocellular cancer	Non metastatic	2002–2016	470	52.2^a	Resection	Univariate	0.7	Retrospective	29^b	OS	7
Margetts [21]	2018	China^A	Hepatocellular cancer	Mixed	2007–2013	585	60^b	Resection + Chemo	Multivariate	1.3	Retrospective	NR	OS	7
Liu [22]	2018	China^A	Nasopharyngeal cancer	Mixed	2007–2012	413	45^b	Chemo	Univariate	1.315	Retrospective	NR	OS, PFS	6
Zhao^c [14]	2017	China^A	Advanced cancer	Mixed	2013–2015	378	64^b	Palliative therapy	Multivariate	0.8	Retrospective	14.83^b	OS	6
Zhao^c [14]	2017	China^A	Advanced cancer	Mixed	2013–2015	378	64^b	Palliative therapy	Multivariate	1.1	Retrospective	14.83^b	OS	6
Zhao^c [14]	2017	China^A	Advanced cancer	Mixed	2013–2015	378	64^b	Palliative therapy	Multivariate	1.5	Retrospective	14.83^b	OS	6
Zhao [14]	2017	China^A	Advanced cancer	Mixed	2013–2015	106	64^b	Palliative therapy	Multivariate	0.8	Retrospective	16.97^b	OS	6
He [15]	2017	China^A	Hepatocellular cancer	Non metastatic	2007–2015	216	53^b	Chemo	Univariate	0.8	Retrospective	NR	OS	8
Bobdey [23]	2017	India^A	Oral cancer	Mixed	2007–2008	471	50^a	Chemo	Univariate	1.98	Retrospective	22^b	OS	6
Xu [24]	2017	China^A	Glioblastoma	Non metastatic	2010–2015	166	50^b	Resection	Multivariate	1.9	Retrospective	14^b	OS	7
Zhang [25]	2017	China^A	Gallbladder cancer	Mixed	2001–2013	98	63^a	Resection	Univariate	2.06	Retrospective	NR	OS	8
Sorensen [26]	2017	Denmark^NA	MBDex	Metastatic	2003–2013	270	64^b	Resection	Multivariate	1.37	Retrospective	8.82^b	OS	6
Oh [27]	2017	Korea^A	Colorectal cancer	Mixed	2006–2011	261	65^b	Resection	Univariate	1.83	Retrospective	78^b	OS	7
Wu [7]	2016	America^NA	Cervical cancer	Non metastatic	1998–2013	71	49^a	Chemo	Multivariate	1.0	Retrospective	30.4^b	OS, PFS	8
Sun [28]	2016	China^A	Gastric cancer	Non metastatic	2000–2012	873	59^b	Resection	Univariate	3	Retrospective	36^b	OS, PFS	8
Sun [29]	2016	China^A	Nasopharyngeal cancer	Non metastatic	2008–2011	251	46^b	Chemo	Multivariate	1.5	Retrospective	41^b	OS,PFS	7
Kou [30]	2016	China^A	Esophagus cancer	Metastatic	2005–2013	215	58^b	Chemo	Multivariate	1.0	Retrospective	120	OS	6
Joseph [9]	2016	UK^NA	Bladder cancer	Non metastatic	2009–2014	131	68^b	Chemo	Multivariate	1.5	Retrospective	17^b	OS	8
Eo [31]	2016	Korea^A	Endometrial cancer	Non metastatic	2005–2014	255	44^b	Resection	Univariate	1.526	Retrospective	51.3^b	OS	7
d’Engremont [32]	2016	France^NA	Pancreatic cancer	Non metastatic	2000–2010	390	NR	Resection	Multivariate	1.0	Retrospective	66.6^b	OS	6
Deng [33]	2016	China^A	Gallbladder cancer	Mixed	2002–2012	315	NR	Resection	Multivariate	1.5	Retrospective	9^b	OS	6
Cho [34]	2016	Korea^A	Lung cancer	Non metastatic	2001–2014	73	65^a	Radiotherapy	Univariate	1.747	Retrospective	22^b	OS, PFS	7
Cho [35]	2016	Korea^A	Cervical cancer	Mixed	2001–2012	124	57^b	Chemoradiotherapy	Multivariate	1.5	Retrospective	63^b	PFS	6
Berardi [36]	2016	Italy^NA	Lung cancer	Mixed	2009–2014	401	68^a	Chemo	Univariate	1.5	Retrospective	80	OS, PFS	7
Zhou [50]	2016	China^A	Gastric cancer	Non metastatic	2006–2008	451	NR	Resection	Univariate	1.5	Retrospective	37.7^b	OS	6
Wild [10]	2015	America^NA	Pancreatic cancer	Non metastatic	1997–2011	101	62^b	Chemo	Univariate	1.0	Retrospective	10.1^b	OS	6
Santoni [11]	2015	Italy^NA	Renal cancer	Mixed	2005–2014	151	64^a	Chemo	Univariate	1.5	Retrospective	51.6^b	OS, PFS	7
Rochet [12]	2015	America^NA	Stage III Melanoma	Non metastatic	2000–2010	153	59^b	Resection	Multivariate	2.1	Retrospective	30^b	OS	7
Rochet [12]	2015	America^NA	Stage IV Melanoma	Metastatic	2000–2010	74	56^b	Resection	Multivariate	1.9	Retrospective	24^b	OS	7
Mehrazin [37]	2015	America^NA	Renal cancer	Non metastatic	2000–2013	192	62^a	Resection	Multivariate	1.3	Retrospective	38.7^b	OS	6
Ku [38]	2015	UK^NA	Urothelial cancer	Non metastatic	1999–2011	419	65.1^b	Resection	Multivariate	1.0	Retrospective	37.7^b	OS	7
Jin [39]	2014	China^A	Nasopharyngeal cancer	Metastatic	2006–2011	229	45^b	Chemo	Multivariate	1.0	Retrospective	84	OS	7
Paik^c [13]	2014	Korea^A	Colorectal cancer	Non metastatic	2006–2009	600	62.3^a	Resection	Univariate	1.0	Retrospective	27,4^b	OS	8
Paik^c [13]	2014	Korea^A	Colorectal cancer	Non metastatic	2006–2009	600	62.3^a	Resection	Univariate	3.0	Retrospective	27,4^b	OS	8
Kumagai [40]	2014	Japan^A	Lung cancer	Non metastatic	2007–2012	302	67^b	Resection	Multivariate	1.4	Retrospective	33.4^b	OS	7
DeGiorgi [41]	2014	Italy^NA	Renal cancer	Metastatic	2006–2011	181	NR	Chemo	Multivariate	1.0	Retrospective	NR	OS, PFS	7
Zhang [42]	2013	China^A	Lung cancer	Mixed	1999–2006	142	57.5^a	Resection	Multivariate	1.8	Retrospective	NR	OS	7
Saroha [8]	2013	America^NA	Renal cancer	Non metastatic	1994–2008	430	60.2^a	Resection	Multivariate	1.3	Retrospective	33.5^b	OS	6
Manuel [43]	2012	France^NA	Breast cancer	Metastatic	NR	66	NR	Chemo	Univariate	1.0	Retrospective	18.8^b	OS	8
Manuel [43]	2012	France^NA	Pancreatic cancer	Metastatic	NR	67	NR	Chemo	Univariate	1.0	Retrospective	14.3^b	OS	8
He^c [44]	2012	China^A	Nasopharyngeal cancer	Non metastatic	2005–2007	1410	46.1^a	Chemo	Multivariate	1.69	Retrospective	41^b	OS, PFS	7
He^c [44]	2012	China^A	Nasopharyngeal cancer	Non metastatic	2005–2007	1410	46.1^a	Chemo	Multivariate	2.06	Retrospective	41^b	OS, PFS	7
He^c [44]	2012	China^A	Nasopharyngeal cancer	Non metastatic	2005–2007	1410	46.1^a	Chemo	Multivariate	2.53	Retrospective	41^b	OS, PFS	6
DeGiorgi [45]	2012	America^NA	Breast cancer	Metastatic	2004–2008	195	54^b	Chemo	Multivariate	1.0	Retrospective	NR	OS, PFS	7
Ceze [46]	2011	France^NA	Colorectal cancer	Non metastatic	1999–2007	260	64.8^a	Chemo	Multivariate	1.0	Retrospective	15^b	OS, PFS	6
Teramukai^c [47]	2009	Japan^A	Lung cancer	Mixed	2001–2005	388	65^b	Chemo	Multivariate	1.082	Retrospective	18.9^b	OS, PFS	7
Teramukai^c [47]	2009	Japan^A	Lung cancer	Mixed	2001–2005	388	65^b	Chemo	Multivariate	1.386	Retrospective	18.9^b	OS, PFS	7
Teramukai^c [47]	2009	Japan^A	Lung cancer	Mixed	2001–2005	388	65^b	Chemo	Multivariate	1.821	Retrospective	18.9^b	OS, PFS	7
Ray-Coquard [1]	2009	France^NA	Breast cancer	Metastatic	NR	287	NR	Chemo	Multivariate	1.0	Retrospective	138	OS, PFS	8
Ray-Coquard [1]	2009	France^NA	Soft tissue sarcoma	Metastatic	NR	193	NR	Chemo	Multivariate	1.0	Retrospective	90	OS, PFS	8
LeScodan [48]	2007	France^NA	Brain metastases	Metastatic	1998–2003	132	54.9^b	Chemo	Multivariate	0.7	Retrospective	25^b	OS	7
Claude [49]	2005	France^NA	Brain metastases	Metastatic	1991–2001	120	54^b	Radiotherapy	Multivariate	0.7	Retrospective	67^b	OS	7

NR not report, OS overall survival, PFS progression free survival, MBDex metastatic bone disease in the extremities
^aMean; ^bmedian; ^cThe same patients sources in different cut-off values; ^AAsian; ^NANon-Asian

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