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Table 1 Main characteristics of the included studies in the meta-analysis

From: Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis

First author Year Region Disease site Disease stage Inclusion period No. of patients Age Treatment Analysis of survival Cut off value (× 109/L) Study design Follow-up (months) Outcome reported NOS score
Yang [19] 2018 ChinaA Hypopharyngeal cancer Non metastatic 2009–2014 197 NR Chemo + Resection Univariate 1.7 Retrospective 30.95b OS 8
Pang [20] 2018 ChinaA Hepatocellular cancer Non metastatic 2002–2016 470 52.2a Resection Univariate 0.7 Retrospective 29b OS 7
Margetts [21] 2018 ChinaA Hepatocellular cancer Mixed 2007–2013 585 60b Resection + Chemo Multivariate 1.3 Retrospective NR OS 7
Liu [22] 2018 ChinaA Nasopharyngeal cancer Mixed 2007–2012 413 45b Chemo Univariate 1.315 Retrospective NR OS, PFS 6
Zhaoc [14] 2017 ChinaA Advanced cancer Mixed 2013–2015 378 64b Palliative therapy Multivariate 0.8 Retrospective 14.83b OS 6
Zhaoc [14] 2017 ChinaA Advanced cancer Mixed 2013–2015 378 64b Palliative therapy Multivariate 1.1 Retrospective 14.83b OS 6
Zhaoc [14] 2017 ChinaA Advanced cancer Mixed 2013–2015 378 64b Palliative therapy Multivariate 1.5 Retrospective 14.83b OS 6
Zhao [14] 2017 ChinaA Advanced cancer Mixed 2013–2015 106 64b Palliative therapy Multivariate 0.8 Retrospective 16.97b OS 6
He [15] 2017 ChinaA Hepatocellular cancer Non metastatic 2007–2015 216 53b Chemo Univariate 0.8 Retrospective NR OS 8
Bobdey [23] 2017 IndiaA Oral cancer Mixed 2007–2008 471 50a Chemo Univariate 1.98 Retrospective 22b OS 6
Xu [24] 2017 ChinaA Glioblastoma Non metastatic 2010–2015 166 50b Resection Multivariate 1.9 Retrospective 14b OS 7
Zhang [25] 2017 ChinaA Gallbladder cancer Mixed 2001–2013 98 63a Resection Univariate 2.06 Retrospective NR OS 8
Sorensen [26] 2017 DenmarkNA MBDex Metastatic 2003–2013 270 64b Resection Multivariate 1.37 Retrospective 8.82b OS 6
Oh [27] 2017 KoreaA Colorectal cancer Mixed 2006–2011 261 65b Resection Univariate 1.83 Retrospective 78b OS 7
Wu [7] 2016 AmericaNA Cervical cancer Non metastatic 1998–2013 71 49a Chemo Multivariate 1.0 Retrospective 30.4b OS, PFS 8
Sun [28] 2016 ChinaA Gastric cancer Non metastatic 2000–2012 873 59b Resection Univariate 3 Retrospective 36b OS, PFS 8
Sun [29] 2016 ChinaA Nasopharyngeal cancer Non metastatic 2008–2011 251 46b Chemo Multivariate 1.5 Retrospective 41b OS,PFS 7
Kou [30] 2016 ChinaA Esophagus cancer Metastatic 2005–2013 215 58b Chemo Multivariate 1.0 Retrospective 120 OS 6
Joseph [9] 2016 UKNA Bladder cancer Non metastatic 2009–2014 131 68b Chemo Multivariate 1.5 Retrospective 17b OS 8
Eo [31] 2016 KoreaA Endometrial cancer Non metastatic 2005–2014 255 44b Resection Univariate 1.526 Retrospective 51.3b OS 7
d’Engremont [32] 2016 FranceNA Pancreatic cancer Non metastatic 2000–2010 390 NR Resection Multivariate 1.0 Retrospective 66.6b OS 6
Deng [33] 2016 ChinaA Gallbladder cancer Mixed 2002–2012 315 NR Resection Multivariate 1.5 Retrospective 9b OS 6
Cho [34] 2016 KoreaA Lung cancer Non metastatic 2001–2014 73 65a Radiotherapy Univariate 1.747 Retrospective 22b OS, PFS 7
Cho [35] 2016 KoreaA Cervical cancer Mixed 2001–2012 124 57b Chemoradiotherapy Multivariate 1.5 Retrospective 63b PFS 6
Berardi [36] 2016 ItalyNA Lung cancer Mixed 2009–2014 401 68a Chemo Univariate 1.5 Retrospective 80 OS, PFS 7
Zhou [50] 2016 ChinaA Gastric cancer Non metastatic 2006–2008 451 NR Resection Univariate 1.5 Retrospective 37.7b OS 6
Wild [10] 2015 AmericaNA Pancreatic cancer Non metastatic 1997–2011 101 62b Chemo Univariate 1.0 Retrospective 10.1b OS 6
Santoni [11] 2015 ItalyNA Renal cancer Mixed 2005–2014 151 64a Chemo Univariate 1.5 Retrospective 51.6b OS, PFS 7
Rochet [12] 2015 AmericaNA Stage III Melanoma Non metastatic 2000–2010 153 59b Resection Multivariate 2.1 Retrospective 30b OS 7
Rochet [12] 2015 AmericaNA Stage IV Melanoma Metastatic 2000–2010 74 56b Resection Multivariate 1.9 Retrospective 24b OS 7
Mehrazin [37] 2015 AmericaNA Renal cancer Non metastatic 2000–2013 192 62a Resection Multivariate 1.3 Retrospective 38.7b OS 6
Ku [38] 2015 UKNA Urothelial cancer Non metastatic 1999–2011 419 65.1b Resection Multivariate 1.0 Retrospective 37.7b OS 7
Jin [39] 2014 ChinaA Nasopharyngeal cancer Metastatic 2006–2011 229 45b Chemo Multivariate 1.0 Retrospective 84 OS 7
Paikc [13] 2014 KoreaA Colorectal cancer Non metastatic 2006–2009 600 62.3a Resection Univariate 1.0 Retrospective 27,4b OS 8
Paikc [13] 2014 KoreaA Colorectal cancer Non metastatic 2006–2009 600 62.3a Resection Univariate 3.0 Retrospective 27,4b OS 8
Kumagai [40] 2014 JapanA Lung cancer Non metastatic 2007–2012 302 67b Resection Multivariate 1.4 Retrospective 33.4b OS 7
DeGiorgi [41] 2014 ItalyNA Renal cancer Metastatic 2006–2011 181 NR Chemo Multivariate 1.0 Retrospective NR OS, PFS 7
Zhang [42] 2013 ChinaA Lung cancer Mixed 1999–2006 142 57.5a Resection Multivariate 1.8 Retrospective NR OS 7
Saroha [8] 2013 AmericaNA Renal cancer Non metastatic 1994–2008 430 60.2a Resection Multivariate 1.3 Retrospective 33.5b OS 6
Manuel [43] 2012 FranceNA Breast cancer Metastatic NR 66 NR Chemo Univariate 1.0 Retrospective 18.8b OS 8
Manuel [43] 2012 FranceNA Pancreatic cancer Metastatic NR 67 NR Chemo Univariate 1.0 Retrospective 14.3b OS 8
Hec [44] 2012 ChinaA Nasopharyngeal cancer Non metastatic 2005–2007 1410 46.1a Chemo Multivariate 1.69 Retrospective 41b OS, PFS 7
Hec [44] 2012 ChinaA Nasopharyngeal cancer Non metastatic 2005–2007 1410 46.1a Chemo Multivariate 2.06 Retrospective 41b OS, PFS 7
Hec [44] 2012 ChinaA Nasopharyngeal cancer Non metastatic 2005–2007 1410 46.1a Chemo Multivariate 2.53 Retrospective 41b OS, PFS 6
DeGiorgi [45] 2012 AmericaNA Breast cancer Metastatic 2004–2008 195 54b Chemo Multivariate 1.0 Retrospective NR OS, PFS 7
Ceze [46] 2011 FranceNA Colorectal cancer Non metastatic 1999–2007 260 64.8a Chemo Multivariate 1.0 Retrospective 15b OS, PFS 6
Teramukaic [47] 2009 JapanA Lung cancer Mixed 2001–2005 388 65b Chemo Multivariate 1.082 Retrospective 18.9b OS, PFS 7
Teramukaic [47] 2009 JapanA Lung cancer Mixed 2001–2005 388 65b Chemo Multivariate 1.386 Retrospective 18.9b OS, PFS 7
Teramukaic [47] 2009 JapanA Lung cancer Mixed 2001–2005 388 65b Chemo Multivariate 1.821 Retrospective 18.9b OS, PFS 7
Ray-Coquard [1] 2009 FranceNA Breast cancer Metastatic NR 287 NR Chemo Multivariate 1.0 Retrospective 138 OS, PFS 8
Ray-Coquard [1] 2009 FranceNA Soft tissue sarcoma Metastatic NR 193 NR Chemo Multivariate 1.0 Retrospective 90 OS, PFS 8
LeScodan [48] 2007 FranceNA Brain metastases Metastatic 1998–2003 132 54.9b Chemo Multivariate 0.7 Retrospective 25b OS 7
Claude [49] 2005 FranceNA Brain metastases Metastatic 1991–2001 120 54b Radiotherapy Multivariate 0.7 Retrospective 67b OS 7
  1. NR not report, OS overall survival, PFS progression free survival, MBDex metastatic bone disease in the extremities
  2. aMean; bmedian; cThe same patients sources in different cut-off values; AAsian; NANon-Asian