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Table 2 Subgroup analysis of the meta-analysis for OS

From: Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis

Subgroup No. of studies No. of patients Pooled HR 95% CI P Heterogeneity test Statistical method
I2 P
Treatment
 Resection [8, 12, 13, 20, 24,25,26,27,28, 31,32,33, 37, 38, 40, 42, 50] 17 5861 1.30 1.08–1.55 0.004 61.5% <0.001 Random
 Chemo [1, 7, 9,10,11, 15, 22, 23, 29, 30, 36, 39, 41, 43,44,45,46,47] 18 5687 1.64 1.00–2.71 < 0.001 60.0% <0.001 Random
Analysis of survival
 Multivariate [1, 7,8,9, 12, 14, 21, 24, 26, 29, 30, 32, 33, 37,38,39,40,41,42, 44,45,46,47,48,49] 25 7612 1.31 1.16–1.47 < 0.001 63.6% <0.001 Random
 Univariate [10, 11, 13, 15, 19, 20, 22, 23, 25, 27, 28, 31, 34, 36, 43, 50] 16 5536 1.20 1.02–1.40 0.023 46.6% 0.016 Random
Cut-off value
 ≤ 1.0 [1, 7, 10, 13,14,15, 20, 30, 32, 38, 39, 41, 43, 45, 46, 48, 49] 17 4437 1.46 1.21–1.77 < 0.001 67.6% <0.001 Random
 1.0 to < 2.0 [8, 9, 11, 12, 14, 19, 21,22,23,24, 26, 27, 29, 31, 33, 34, 36, 40, 42, 44, 47, 50] 22 7646 1.18 1.06–1.31 0.004 49.6% 0.002 Random
 ≥ 2.0 [12, 13, 25, 28, 44] 5 4544 1.16 0.96–1.39 0.121 0.0% 0.760 Random
Disease site
 Colorectal cancer [13, 27, 46] 3 1121 1.96 1.36–2.83 < 0.001 0.0% 0.737 Random
 Breast cancer [1, 43, 45] 3 454 1.82 1.43–2.31 < 0.001 0.0% 0.509 Random
 Renal cancer [8, 11, 37, 41] 4 954 1.65 1.22–2.24 0.001 24.3% 0.265 Random
 Lung cancer [34, 36, 40, 42, 47] 5 1306 1.20 0.92–1.57 0.177 63.9% 0.011 Random
 Pancreatic cancer [10, 32, 43] 3 558 1.56 0.88–2.15 0.129 73.5% 0.023 Random
 Nasopharyngeal cancer [22, 29, 39, 44] 4 2303 1.23 1.03–1.46 0.017 0.0% 0.701 Random
 Gallbladder cancer [25, 33] 2 511 1.05 0.637–1.75 0.828 77.7% 0.034 Random
 Gastric cancer [28, 50] 2 1324 1.10 0.85–1.43 0.442 29.9% 0.232 Random
Disease stage
 Non metastatic [7,8,9,10, 12, 13, 15, 19, 20, 24, 28, 29, 31, 32, 34, 37, 38, 40, 44, 46, 50] 21 7437 1.32 1.12–1.54 < 0.001 58.0% 0.001 Random
 Metastatic [1, 12, 26, 30, 39, 41, 43, 45, 48, 49] 10 2108 1.54 1.24–1.92 < 0.001 60.2% 0.004 Random
 Mixed [11, 14, 21,22,23, 25, 27, 33, 36, 42, 47] 11 3603 1.09 0.98–1.20 0.107 26.2% 0.160 Random
Region
 Asian [13,14,15, 19,20,21,22,23,24,25, 27,28,29,30,31, 33, 34, 39, 40, 42, 44, 47, 50] (China, India, Korea, Japan) 23 8422 1.10 0.99–1.21 0.08 48.6% 0.001 Random
 Non-Asian [1, 7,8,9,10,11,12, 26, 32, 36,37,38, 41, 43, 45, 46, 48, 49] (Denmark, America, UK, France, Italy) 18 4726 1.27 1.16–1.39 < 0.001 32.0% 0.080 Random