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Table 2 Subgroup analysis of the meta-analysis for OS

From: Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis

Subgroup

No. of studies

No. of patients

Pooled HR

95% CI

P

Heterogeneity test

Statistical method

I2

P

Treatment

 Resection [8, 12, 13, 20, 24,25,26,27,28, 31,32,33, 37, 38, 40, 42, 50]

17

5861

1.30

1.08–1.55

0.004

61.5%

<0.001

Random

 Chemo [1, 7, 9,10,11, 15, 22, 23, 29, 30, 36, 39, 41, 43,44,45,46,47]

18

5687

1.64

1.00–2.71

< 0.001

60.0%

<0.001

Random

Analysis of survival

 Multivariate [1, 7,8,9, 12, 14, 21, 24, 26, 29, 30, 32, 33, 37,38,39,40,41,42, 44,45,46,47,48,49]

25

7612

1.31

1.16–1.47

< 0.001

63.6%

<0.001

Random

 Univariate [10, 11, 13, 15, 19, 20, 22, 23, 25, 27, 28, 31, 34, 36, 43, 50]

16

5536

1.20

1.02–1.40

0.023

46.6%

0.016

Random

Cut-off value

 ≤ 1.0 [1, 7, 10, 13,14,15, 20, 30, 32, 38, 39, 41, 43, 45, 46, 48, 49]

17

4437

1.46

1.21–1.77

< 0.001

67.6%

<0.001

Random

 1.0 to < 2.0 [8, 9, 11, 12, 14, 19, 21,22,23,24, 26, 27, 29, 31, 33, 34, 36, 40, 42, 44, 47, 50]

22

7646

1.18

1.06–1.31

0.004

49.6%

0.002

Random

 ≥ 2.0 [12, 13, 25, 28, 44]

5

4544

1.16

0.96–1.39

0.121

0.0%

0.760

Random

Disease site

 Colorectal cancer [13, 27, 46]

3

1121

1.96

1.36–2.83

< 0.001

0.0%

0.737

Random

 Breast cancer [1, 43, 45]

3

454

1.82

1.43–2.31

< 0.001

0.0%

0.509

Random

 Renal cancer [8, 11, 37, 41]

4

954

1.65

1.22–2.24

0.001

24.3%

0.265

Random

 Lung cancer [34, 36, 40, 42, 47]

5

1306

1.20

0.92–1.57

0.177

63.9%

0.011

Random

 Pancreatic cancer [10, 32, 43]

3

558

1.56

0.88–2.15

0.129

73.5%

0.023

Random

 Nasopharyngeal cancer [22, 29, 39, 44]

4

2303

1.23

1.03–1.46

0.017

0.0%

0.701

Random

 Gallbladder cancer [25, 33]

2

511

1.05

0.637–1.75

0.828

77.7%

0.034

Random

 Gastric cancer [28, 50]

2

1324

1.10

0.85–1.43

0.442

29.9%

0.232

Random

Disease stage

 Non metastatic [7,8,9,10, 12, 13, 15, 19, 20, 24, 28, 29, 31, 32, 34, 37, 38, 40, 44, 46, 50]

21

7437

1.32

1.12–1.54

< 0.001

58.0%

0.001

Random

 Metastatic [1, 12, 26, 30, 39, 41, 43, 45, 48, 49]

10

2108

1.54

1.24–1.92

< 0.001

60.2%

0.004

Random

 Mixed [11, 14, 21,22,23, 25, 27, 33, 36, 42, 47]

11

3603

1.09

0.98–1.20

0.107

26.2%

0.160

Random

Region

 Asian [13,14,15, 19,20,21,22,23,24,25, 27,28,29,30,31, 33, 34, 39, 40, 42, 44, 47, 50] (China, India, Korea, Japan)

23

8422

1.10

0.99–1.21

0.08

48.6%

0.001

Random

 Non-Asian [1, 7,8,9,10,11,12, 26, 32, 36,37,38, 41, 43, 45, 46, 48, 49] (Denmark, America, UK, France, Italy)

18

4726

1.27

1.16–1.39

< 0.001

32.0%

0.080

Random

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