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Fig. 2 | Cancer Cell International

Fig. 2

From: Capicua suppresses colorectal cancer progression via repression of ETV4 expression

Fig. 2

CIC suppresses CRC progression. a Western blot analysis presenting the overexpression and knockout of CIC in HCT116 and HT29 CRC cells. b Cell growth assay of the CIC-S-overexpressing and CIC-deficient (CIC KO) CRC cells. c In vivo subcutaneous tumor growth curves of control and CIC KO HCT116 cells. n = 7 per each group. The inset image is a representative image of xenograft tumors dissected from the mice after the last measurement of tumor size. The right panel is a graph for average weights of the dissected tumors. d, e Matrigel invasion (d) and trans-well migration (e) assay of control, CIC KO, and CIC-overexpressing CRC cells. The bottom panels are bar graphs for quantification of cell invasiveness (d) and cell migration (e), respectively. Three independent experiments were performed. All error bars indicate s.e.m. *P < 0.05, **P < 0.01, and ***P < 0.001

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