Fig. 8From: A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS productsSchematic diagram of the mechanism of lj-1-59. lj-1-59 induces DNA damage by increasing intracellular ROS levels. ATM and ATR are activated after DNA damage, then regulating downstream target protein P53, leading to cell cycle arrest and apoptosisBack to article page