Table 3 LncRNAs dysregulated in pancreatic cancer

HOTAIR

LncRNA HOX transcript antisense RNA

Up

Related to cancer cell proliferation, progression and invasion

[4]

HOTTIP

HOXA transcript at the distal tip

Up

Promotes cancer cell proliferation, inhibits cell apoptosis, increases migration

[54]

MALAT-1

Metastasis-associated lung adenocarcinoma transcript 1

Up

Regulates the cell cycle, growth, migration and invasion

[19]

H19

LncRNA H19

Up

Enhances pancreatic cancer cell proliferation

[90]

ENST00000480739

LncRNA ENST00000480739

Down

Cell proliferation, invasion and migration

[69]

BC008363

LncRNA BC008363

Down

Potential critical role in tumorigenesis

[84]

PVT1

Plasmacytoma variant translocation 1

Up

Unknown

[75]

GAS5

Growth arrest-specific 5

Down

Inhibits cell proliferation

[86]

NEAT1

p53-inducible lincRNA

Down

Promotes neoplasia

[65]

SNHG 15

16

Small nucleolar RNA host gene

Up

Regulation of cell proliferation, migration and invasion of tumors

[59, 61]

ZEB2-AS1

 LncRNA ZEB2-AS1

Up

Cell growth and invasion

[79]

TUG1

Taurine upregulated 1

Up

Cell proliferation, invasion, and migration

[73, 74]

XIST

LncRNA X inactive-specific transcript

Up

Promotes proliferation, migration and invasion

[25]

MEG3

LncRNA MEG3

Down

Tumor suppressor

[91, 92]

DUXAP8

A pseudogene-derived lncRNA

Up

Cell proliferation and promotes apoptosis in vitro and in vivo

[70]

XLOC-000647

LncRNA XLOC-000647

Down

Cell proliferation and invasion

[63]

IRAIN

LncRNA IRAIN

Up

Cell apoptosis and induces growth arrest

[66]

DLEU2

LncRNA DLEU2

Up

Cell proliferation and invasion

[12]

HULC

LncRNA HULC

Up

Cell proliferation, migration and invasion

[68]

PCTST

LncRNA PCTST

Down

Inhibits cell proliferation, invasion, tumorigenesis and EMT

[73]