Fig. 2
From: MicroRNA-4316 inhibits gastric cancer proliferation and migration via directly targeting VEGF-A
Over-expression of miR-4316 inhibited of gastric cells proliferation, migration and colony formation. a, b MiR-4316 levels were increased and decreased in SGC-7901 and BGC-823 cells transfected with miR-4316-mimic and miR-4316-inhibitor. c SGC-7901 and BGC-823 cells were transfected with miR-4316-mimic, miR-inhibitor, or N.C for 0, 24, 48, and 72 h. The cell proliferation was performed by CCK-8. d SGC-7901 and BGC-823 cells were transfected with miR-4316-mimic, miR-inhibitor, or N.C for 48 h. Then migrated area was shown in d. e SGC-7901 and BGC-823 cells were transfected with miR-4316-mimic, miR-4316-inhibitor, or N.C for 24 h. The cells migration was detected by transwell assay. The migrated cells were accounted per field ×20 for SGC-7901 and ×40 for BGC-823 as shown in e. f Colony formation assay of the changes in proliferation capacity of SGC-7901 and BGC-823 cells after transfection with miR-4316-mimic, miR-inhibitor, or N.C for 14 days. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001