Fig. 4
From: Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer
CAV-2 is a downstream target of BRD4. a RNA sequence was employed to identify the downstream target of BRD4. The results showed that there were 27 differentially expressed gene, 12 upregulations and 15 downregulation. Among them, the downregulation of CAV-2 was the second most. b, c The CAV-2 mRNA (b) and protein (c) level in both BRD4-si1 and BRD4-si2 group was down-regulated. d, e Compared to BRD4-ctrl group, the CAV-2 mRNA (d) and protein (e) in BRD4-over group was up-regulated. f Sulforhodamine B assays showed that both CAV-2-si1 and CAV-2-si2 group significantly suppressed cell proliferation compared to CAV-2-nc group. g Sulforhodamine B assays showed that CAV-2-over group significantly promoted cell proliferation compared to BRD4-ctrl group. h Migration assay showed that both CAV-2-si1 and CAV-2-si2 group did not significantly suppressed cell migration and invasion compared to CAV-2-nc group. i Migration assay showed that BRD4-over group did not significantly increased cell migration and invasion compared to BRD4-ctrl group. The asterisk indicates that p is less than 0.05