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Fig. 5 | Cancer Cell International

Fig. 5

From: Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer

Fig. 5

CAV-2 overexpression partially restores BRD4-siRNA mediated cell proliferation. a Western blot was employed to detect BRD4, CAV-2, PCNA, C-myc, CDK2, and pRb expression when cotransfected CFPAC-1 and PANC-1 cells with BRD4 nc/siRNA and CAV-2 ctrl/over plasmid. BRD4 decreased PCNA, C-myc, CDK2, and pRb expression. CAV-2 overexpression can partially reverse the protein expression of BRD4 suppression. b, c. Sulforhodamine B assays (b) and plate clone formations (c) showed that CAV-2 overexpression partially reversed decreased cell proliferation of BRD4 knockdown. d Cell cycle experiments showed that suppression of BRD4 induced G1 phase arrest. CAV-2 overexpression can partially reverse the effects of BRD4 knockdown. The asterisk indicates that p is less than 0.05

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