Table 3 Summary of univariate and multivariate Cox regression analysis of overall survival

BRD4

 Low

1

1

 High

3.321

1.592–6.930

0.001*

2.244

1.009–4.990

CAV-2

 Low

1

1

 High

3.666

1.881–7.143

< 0.001*

2.370

1.108–5.071

Age (years)

 ≤ 60

1

 > 60

0.765

0.415–1.409

0.390

Gender

 Male

1

 Female

1.116

0.600–2.076

0.728

Clinical stage

 Early stages (≤ I)

1

1

 Advanced stages (> I)

4.059

1.255–13.123

0.019*

2.120

0.560–8.025

Invasion depth

 T1 + T2

1

 T3 + T4

1.937

0.864–4.342

0.109

Lymph nodes metastasis

 N0 (negative)

1

 N1 (positive)

1.264

0.699–2.284

0.439

Distant metastasis

 M0 (Absent)

1

 M1 (Present)

0.597

0.144–2.468

0.476

Tumor differentiation

 Well, moderate

1

1

 Poor

1.963

1.084–3.553

0.026*

1.798

0.916–3.530

Tumor location

 Head, neck

1

 Body, tail

1.541

0.854–2.779

0.151

Nervous invasion

 Negative

1

1

 Positive

2.018

1.020–3.993

0.044*

0.995

0.470–2.106

Vessel invasion

 Negative

1

1

 Positive

4.107

1.978–8.528

< 0.001*

4.100

1.715–9.804