From: Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer
Characteristics | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
BRD4 | ||||||
 Low | 1 |  |  | 1 |  |  |
 High | 3.321 | 1.592–6.930 | 0.001* | 2.244 | 1.009–4.990 | 0.047* |
CAV-2 | ||||||
 Low | 1 |  |  | 1 |  |  |
 High | 3.666 | 1.881–7.143 | < 0.001* | 2.370 | 1.108–5.071 | 0.026* |
Age (years) | ||||||
 ≤ 60 | 1 |  |  |  |  |  |
 > 60 | 0.765 | 0.415–1.409 | 0.390 |  |  |  |
Gender | ||||||
 Male | 1 |  |  |  |  |  |
 Female | 1.116 | 0.600–2.076 | 0.728 |  |  |  |
Clinical stage | ||||||
 Early stages (≤ I) | 1 |  |  | 1 |  |  |
 Advanced stages (> I) | 4.059 | 1.255–13.123 | 0.019* | 2.120 | 0.560–8.025 | 0.269 |
Invasion depth | ||||||
 T1 + T2 | 1 |  |  |  |  |  |
 T3 + T4 | 1.937 | 0.864–4.342 | 0.109 |  |  |  |
Lymph nodes metastasis | ||||||
 N0 (negative) | 1 |  |  |  |  |  |
 N1 (positive) | 1.264 | 0.699–2.284 | 0.439 |  |  |  |
Distant metastasis | ||||||
 M0 (Absent) | 1 |  |  |  |  |  |
 M1 (Present) | 0.597 | 0.144–2.468 | 0.476 |  |  |  |
Tumor differentiation | ||||||
 Well, moderate | 1 |  |  | 1 |  |  |
 Poor | 1.963 | 1.084–3.553 | 0.026* | 1.798 | 0.916–3.530 | 0.088 |
Tumor location | ||||||
 Head, neck | 1 |  |  |  |  |  |
 Body, tail | 1.541 | 0.854–2.779 | 0.151 |  |  |  |
Nervous invasion | ||||||
 Negative | 1 |  |  | 1 |  |  |
 Positive | 2.018 | 1.020–3.993 | 0.044* | 0.995 | 0.470–2.106 | 0.990 |
Vessel invasion | ||||||
 Negative | 1 |  |  | 1 |  |  |
 Positive | 4.107 | 1.978–8.528 | < 0.001* | 4.100 | 1.715–9.804 | 0.002* |