Fig. 2
From: TRIP6 enhances stemness property of breast cancer cells through activation of Wnt/β-catenin
TRIP6 promotes the proliferation and tumorigenicity of breast cancer cells. a Confirmation of the overexpression and knockdown of TRIP6 in ZR-75-30 and MDA-MB-231 cells; GAPDH was used as a loading control. b, c MTT and colony formation assays indicated that the growth rates increased in TRIP6-transduced breast cancer cells and decreased in TRIP6-silenced breast cancer cells. The number of colonies was quantified in the colony formation assay. Error bars represent the mean ± SD of three independent experiments. *P < 0.05. d ZR-75-30 cells with overexpression of TRIP6 and silencing TRIP6 were inoculated into the fat pad (n = 5/group) of mice. A representative image of each group of mouse tumors (left). Indicates the tumor volume growth curve (center) and average tumor weight (right) of the tumor formed by the indicated cells. Error bars represents the mean ± SD. *P < 0.01