Fig. 1

FER1L4 was downregulated in prostate cancer. a Analysis of TCGA-PRAD data showed that FER1L4 was downregulated in prostate cancer tissues (n = 492) compared with normal prostate tissues (n = 152). b RT-qPCR was performed to investigate the expression of FER1L4 in our collected prostate cancer tissues (n = 78) compared with matched normal prostate tissues (n = 78). The results showed that FER1L4 was decreased in tumors. c Relatively lower expression of FER1L4 was observed in later stage prostate cancer tissues (III–IV) compared with those of early stage (I–II). d RT-qPCR was performed to detect FER1L4 expression in a panel of prostate cancer cell lines and the immortal normal prostate cells. It was showed that FER1L4 was downregulated in prostate cancer cell lines (PC-3, DU145, LNCaP) compared with the immortal normal prostate cell line (RWPE2). **p < 0.01; ***p < 0.001