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Fig. 4 | Cancer Cell International

Fig. 4

From: Long non-coding RNA FER1L4 inhibits prostate cancer progression via sponging miR-92a-3p and upregulation of FBXW7

Fig. 4

FBXW7 was a target gene of miR-92a-3p in prostate cancer. a Using TargetScan, sequencing alignment showed that there was a conserved binding site for miR-92a-3p on the 3′UTR of FBXW7 mRNA. b With GEPIA software, bioinformatic analysis indicated that there was a strong positive correlation between FBXW7 expression and FER1L4 expression in prostate cancer tissues. c, d Western blotting showed that inhibition of miR-92a-3p elevated FBXW7 protein expression in PC-3 (c) and DU145 cells (d). e, f Western blotting showed that overexpression of FER1L4 increased FBXW7 protein expression in PC-3 (e) and DU145 cells (f). g, h RT-qPCR showed that inhibition of miR-92a-3p or overexpression of FER1L4 increased FBXW7 mRNA expression in PC-3 (g) and DU145 cells (h). **p < 0.01; ***p < 0.001

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