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Fig. 7 | Cancer Cell International

Fig. 7

From: Long non-coding RNA FER1L4 inhibits prostate cancer progression via sponging miR-92a-3p and upregulation of FBXW7

Fig. 7

FER1L4 regulated cell proliferation and apoptosis via controlling FBXW7 expression in prostate cancer cells. a, b Transfection of FBXW7 siRNA decreased FBXW7 protein expression in PC-3 (a) and DU145 cells (b). c, d Overexpression of FER1L4 decreased the ratio of p-AKT/AKT protein which was reversed after FBXW7 silencing in PC-3 (c) and DU145 cells (d). e, f FBXW7 silencing attenuated cell apoptosis induced by FER1L4 overexpression in PC-3 (e) and DU145 cells (f). g, h FBXW7 silencing attenuated cell proliferation inhibition induced by FER1L4 overexpression in PC-3 (g) and DU145 cells (h). **p < 0.01; ***p < 0.001

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