Fig. 3
From: Skp2 modulates proliferation, senescence and tumorigenesis of glioma
Downregulation of Skp2 sensitized glioma cells to TMZ. a After Skp2 knockdown, the cell sensitivity to TMZ (inhibition rate) was enhanced in all three cell lines (except sh532 of LNZ308 cells). b The IC50 of TMZ was reduced when Skp2 was knocked down in three cell lines. c The time course of tumor cell sensitivity to TMZ in vivo. d Tumor progression starting from the day TMZ was added. e, f Tumors and their corresponding weights after removal from the mice, sacrificed 24 days after TMZ treatment. ***p < 0.001