Fig. 4
From: Skp2 modulates proliferation, senescence and tumorigenesis of glioma
Downregulation of Skp2 reduced sphere formation ability of glioma stem-like cells and induced cellular senescence. a Skp2 protein levels were enhanced together with the glioma stem cell markers Nestin and Sox2 after enrichment with stem cell conditional medium in three glioma cell lines. b The sphere formation ability was reduced in all three cell lines upon Skp2 knockdown. c Cellular senescence was enhanced in the three cell lines upon Skp2 knockdown. **p < 0.01, ***p < 0.001