Fig. 5
From: Skp2 modulates proliferation, senescence and tumorigenesis of glioma
Combination therapy of TMZ and lovastatin or SZL-P1-41 was more effective than TMZ alone. a, b The chemical structures of lovastatin and SZL-P1-41. c–e The inhibitory effect was increased by the combined treatment of TMZ with lovastatin or SZL-P1-41, as shown in the left panels; in the right panels, the protein level of Skp2 and downstream targets p21Cip1/Waf1, p27Kip1 upon different treatments. f Tumor progression upon TMZ and lovastatin or SZL-P1-41 treatment. g, h Tumors and their corresponding weights from sacrificed mice. LV: lovastatin, SP: SZL-P1-41. *p < 0.05***p < 0.001