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Fig. 1 | Cancer Cell International

Fig. 1

From: Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway

Fig. 1

Expression of hsa_circ_003281 (circ_0032821) was upregulated in human gastric cancer (GC) tissue and cells. a Ten top upregulated circRNAs and ten downregulated circRNAs were presented according to Gene Expression Omnibus database (GEO, GSE78092). b, c These 20 circRNAs were detected in this cohort of gastric cancer patients (n = 60) using RT-qPCR. N, normal adjacent tissue; T, tumor tissue. d The schematic diagram of genomic location of circ_0032821. e RT-qPCR detected circ_0032821 levels in GC tumor tissues at low Tumor node metastasis (TNM) stage (I + II, n = 36) and advanced TNM stage (III + IV, n = 24). f RT-qPCR detected circ_0032821 levels in primary GC tumor tissues (n = 38) and metastatic tumor tissues in lymphoid node (n = 22). g Kaplan–Meier survival plots analyzed the overall survival rate of this cohort of GC patients with high (≥ Median, n = 30) or low (< Median, n = 30) expression of circ_0032821. h Circ_0032821 expression level was tested in the human GC cell lines (AGS, HGC-27, MKN74, MKN1, and SNU-1) and normal gastric epithelial cells GES-1. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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