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Fig. 4 | Cancer Cell International

Fig. 4

From: Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway

Fig. 4

Overexpression of circ_0032821 facilitated cell proliferation, EMT, migration and invasion in human GC cells in vitro. AGS and HGC-27 cells were transfected with circ_0032821 overexpression vector (circ_0032821 vector) or the empty vectors (Vector). a RT-qPCR detected circ_0032821 level after transfection for 1 day. b, c Cell proliferative ability was assessed by CCK-8 after transfection for 3 days. d, e Cell migratory and invasive abilities were evaluated by transwell assays. Western blotting measured protein expression of f, g PCNA, MMP2 and MMP9, and h, i E-cadherin, N-cadherin and Vimentin in transfected AGS and HGC-27 cells on 1 day. *P < 0.05

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