A four-DNA methylation signature as a novel prognostic biomarker for survival of patients with gastric cancer

Table 2 Results of Kaplan–Meier and ROC analysis based on different subgroups

Characteristic	Group	Sample size	Kaplan–Meier P value	AUC	CI 95%
Sex	Female	123	P < 0.001	0.69	0.37–0.78
Sex	Male	245	3.65E−08	0.68	0.49–0.84
Pathologic T	T1–2	93	0.04	0.67	0.44–0.85
Pathologic T	T3–4	275	1.77E−11	0.67	0.48–0.85
Pathologic N	N0	113	0.17	0.53	0.36–0.76
Pathologic N	N1–3	255	7.72E−10	0.72	0.44–0.81
Pathologic M	M0	334	4.36E−10	0.68	0.51–0.77
Pathologic M	M1–3	34	0.09	0.64	NA–NA
Pathological stage	I–II	166	0.001	0.60	0.42–0.79
Pathological stage	III–IV	202	6.91E−07	0.72	0.48–0.83
Histologic grade	G1–2	139	0.002	0.64	0.57–0.88
Histologic grade	G3–4	229	9.17E−10	0.70	0.38–0.74
Anatomic subdivision	Antrum	134	0.003	0.59	0.30–0.81
	Cardia	49	0.005	0.71	0.085–1.0
	Fundus	134	3.79E−08	0.75	0.50–0.95
	GEJ	42	P < 0.001	0.82	NA–NA
	NOS	9	0.35	0.92	NA–NA

ISSN: 1475-2867