Fig. 3

Circ_0072083 could modulate the expression of miR-545-3p through directly binding to miR-545-3p. a The complementary sites marked in red between miR-545-3p and circ_0072083 were predicted by starBase database. b, c Dual-luciferase reporter assay was carried out to verify the target relationship between miR-545-3p and circ_0072083. d, e RIP assay was performed to validate the combination between miR-545-3p and circ_0072083. f The expression of miR-545-3p in NSCLC tissues and corresponding normal tissues was determined by qRT-PCR. g The level of miR-545-3p in a panel of three lung cell lines, including normal human lung epithelial cell line BEAS-2B and two NSCLC cell lines (H522 and A549) was examined by qRT-PCR. h, i The relative expression of miR-545-3p in si-NC or si-circ_0072083 transfected NSCLC cells was examined by qRT-PCR. *P < 0.05