Fig. 4

PPI networks of the DEGs and modular analysis. a, b PPI networks of DEGs using the STRING tool. Genes are represented as nodes in the plot, and their interactions were denoted by lines. The size and color of the nodes represent degree values and change pattern, respectively. The gene of lighter color and greater circle show the higher degree values in this network, whereas the darker color and the smaller circle show the smaller degree values in this network. c Bar-plot of top 30 genes with the most weight. d Top 30 hub genes using MCC algorithm. The color of a node in the PPI network reflects the p value. e Module 1 consists of 10 nodes and 45 edges. f Module 2 consists of 14 nodes and 33 edges. GO (g) and KEGG (h) analysis of genes in the module 1 and module 2. Top five enrichment analysis of GO (include BP, CC, and MF, respectively) and top five pathways KEGG analysis of DEGs. GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, BP biological process, CC, cellular component, MF molecular function