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Table 2 The details of candidate SNPs in IL-1B/IL-1RN and the allele model for the association between these polymorphisms and the risk of head and neck cancer

From: Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Gene

SNP ID

Chr: Position

Alleles

(Ref/Alt)

MAF

Call rate

HWE

OR (95% CI)

p b

Cases

Controls

O(HET)

E(HET)

p a

IL-1B

rs1143643

2:112,830,725

C/T

0.528

0.476

100.0%

0.506

0.499

0.796

1.23 (1.04–1.46)

0.016*

IL-1B

rs1143630

2:112,834,078

G/T

0.163

0.161

100.0%

0.273

0.270

0.874

1.01 (0.81–1.28)

0.908

IL-1B

rs1143627

2:112,836,810

G/A

0.520

0.493

99.8%

0.496

0.500

0.863

1.11 (0.94–1.32)

0.210

IL-1B

rs16944

2:112,837,290

A/G

0.525

0.494

99.9%

0.494

0.500

0.796

1.13 (0.96–1.34)

0.154

IL-1B

rs1143623

2:112,838,252

C/G

0.409

0.417

100.0%

0.403

0.486

< 0.001*

  

IL-1RN

rs17042888

2:113,104,596

G/A

0.242

0.271

100.0%

0.413

0.396

0.383

0.86 (0.71–1.04)

0.120

IL-1RN

rs315919

2:113,118,636

T/G

0.375

0.409

100.0%

0.480

0.483

0.859

0.87 (0.73–1.03)

0.105

IL-1RN

rs3181052

2:113,128,472

A/G

0.392

0.421

100.0%

0.470

0.488

0.426

0.89 (0.75–1.05)

0.165

IL-1RN

rs452204

2:113,131,484

A/G

0.326

0.354

99.5%

0.448

0.458

0.637

0.88 (0.74–1.05)

0.167

  1. SNP Single nucleotide polymorphism, MAF Minor allele frequency, HWE Hardy-Weinberg equilibrium, O(HET) Observed heterozygosity frequency, E(HET) Expected heterozygosity frequency
  2. p a values were calculated by χ2 test
  3. p b values were calculated by logistic regression analysis with adjustments for age and gender
  4. *p < 0.05 indicates statistical significance