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Table 2 The details of candidate SNPs in IL-1B/IL-1RN and the allele model for the association between these polymorphisms and the risk of head and neck cancer

From: Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Gene SNP ID Chr: Position Alleles
(Ref/Alt)
MAF Call rate HWE OR (95% CI) p b
Cases Controls O(HET) E(HET) p a
IL-1B rs1143643 2:112,830,725 C/T 0.528 0.476 100.0% 0.506 0.499 0.796 1.23 (1.04–1.46) 0.016*
IL-1B rs1143630 2:112,834,078 G/T 0.163 0.161 100.0% 0.273 0.270 0.874 1.01 (0.81–1.28) 0.908
IL-1B rs1143627 2:112,836,810 G/A 0.520 0.493 99.8% 0.496 0.500 0.863 1.11 (0.94–1.32) 0.210
IL-1B rs16944 2:112,837,290 A/G 0.525 0.494 99.9% 0.494 0.500 0.796 1.13 (0.96–1.34) 0.154
IL-1B rs1143623 2:112,838,252 C/G 0.409 0.417 100.0% 0.403 0.486 < 0.001*   
IL-1RN rs17042888 2:113,104,596 G/A 0.242 0.271 100.0% 0.413 0.396 0.383 0.86 (0.71–1.04) 0.120
IL-1RN rs315919 2:113,118,636 T/G 0.375 0.409 100.0% 0.480 0.483 0.859 0.87 (0.73–1.03) 0.105
IL-1RN rs3181052 2:113,128,472 A/G 0.392 0.421 100.0% 0.470 0.488 0.426 0.89 (0.75–1.05) 0.165
IL-1RN rs452204 2:113,131,484 A/G 0.326 0.354 99.5% 0.448 0.458 0.637 0.88 (0.74–1.05) 0.167
  1. SNP Single nucleotide polymorphism, MAF Minor allele frequency, HWE Hardy-Weinberg equilibrium, O(HET) Observed heterozygosity frequency, E(HET) Expected heterozygosity frequency
  2. p a values were calculated by χ2 test
  3. p b values were calculated by logistic regression analysis with adjustments for age and gender
  4. *p < 0.05 indicates statistical significance