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Table 3 The effect of genetic variants in IL-1B/IL-1RN on the susceptibility to head and neck cancer

From: Effects of in IL-1B/IL-1RN variants on the susceptibility to head and neck cancer in a chinese Han population

Gene SNP ID Model Genotype Case Control Adjusted by age and gender
OR (95% CI) p
IL-1B rs1143643 Genotype CC 114 146 1  
  CT 277 272 1.30 (0.97–1.75) 0.080
  TT 144 120 1.54 (1.09–2.17) 0.015*
Dominant CC 114 146 1  
  CT-TT 421 392 1.38 (1.04–1.82) 0.026*
Recessive CC-CT 391 418 1  
  TT 144 120 1.28 (0.97–1.70) 0.080
Log-additive     1.24 (1.04–1.47) 0.015*
IL-1B rs1143630 Genotype GG 378 378 1  
  GT 140 147 0.95 (0.73–1.25) 0.736
  TT 17 13 1.31 (0.63–2.74) 0.473
Dominant GG 378 378 1  
  GT-TT 157 160 0.98 (0.76–1.28) 0.898
Recessive GG-GT 518 525 1  
  TT 17 13 1.33 (0.64–2.76) 0.449
Log-additive     1.02 (0.81–1.28) 0.898
IL-1B rs1143627 Genotype GG 118 139 1  
  GA 278 266 1.23 (0.91–1.66) 0.171
  AA 139 131 1.25 (0.89–1.76) 0.201
Dominant GG 118 139 1  
  GA-AA 417 397 1.24 (0.93–1.64) 0.138
Recessive GG-GA 396 405 1  
  AA 139 131 1.09 (0.82–1.43) 0.559
Log-additive     1.12 (0.94–1.33) 0.205
IL-1B rs16944 Genotype AA 116 139 1  
  AG 276 265 1.25 (0.93–1.68) 0.146
  GG 143 133 1.29 (0.92–1.81) 0.146
Dominant AA 116 139 1  
  AG-GG 419 398 1.26 (0.95–1.67) 0.107
Recessive AA-AG 392 404 1  
  GG 143 133 1.11 (0.84–1.46) 0.462
Log-additive     1.13 (0.96–1.34) 0.151
IL-1RN rs17042888 Genotype GG 310 281 1  
  GA 191 222 0.78 (0.61–1.00) 0.053
  AA 34 35 0.88 (0.54–1.45) 0.622
Dominant GG 310 281 1  
  GA-AA 255 257 0.79 (0.62–1.01) 0.060
Recessive GG-GA 501 503 1  
  AA 34 35 0.98 (0.60–1.59) 0.925
Log-additive     0.86 (0.70–1.04) 0.119
IL-1RN rs315919 Genotype TT 204 189 1  
  TG 261 258 0.94 (0.72–1.22) 0.627
  GG 70 91 0.71 (0.49–1.03) 0.072
Dominant TT 204 189 1  
  TG-GG 331 349 0.88 (0.69–1.13) 0.307
Recessive TT-TG 465 447 1  
  GG 70 91 0.74 (0.53–1.04) 0.080
Log-additive     0.86 (0.73–1.03) 0.103
IL-1RN rs3181052 Genotype AA 196 185 1  
  AG 259 253 0.97 (0.74–1.26) 0.799
  GG 80 100 0.76 (0.53–1.08) 0.123
Dominant AA 196 185 1  
  AG-GG 339 353 0.91 (0.71–1.16) 0.441
Recessive AA-AG 455 438 1  
  GG 80 100 0.77 (0.56–1.06) 0.113
Log-additive     0.89 (0.75–1.05) 0.169
IL-1RN rs452204 Genotype AA 237 226 1  
  AG 243 240 0.97 (0.75–1.25) 0.793
  GG 52 70 0.71 (0.47–1.06) 0.093
Dominant AA 237 226 1  
  AG-GG 295 310 0.91 (0.71–1.16) 0.433
Recessive AA-AG 480 466 1  
  GG 52 70 0.72 (0.49–1.06) 0.092
Log-additive     0.88 (0.74–1.05) 0.166
  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. *p < 0.05 respects the data is statistically significant
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Cancer Cell International

ISSN: 1475-2867

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