Table 5 The effect of genetic variants in IL-1B/IL-1RN on the susceptibility of nasopharyngeal carcinoma and thyroid carcinoma
Gene | SNP ID | Model | Genotype | Control | Nasopharyngeal carcinoma | Thyroid carcinoma | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Case | OR (95% CI) | p | Case | OR (95% CI) | p | |||||
IL-1B | rs1143643 | Allele | C | 564 | 87 | 1 | 371 | 1 | ||
T | 512 | 72 | 1.02 (0.72–1.43) | 0.924 | 425 | 1.26 (1.05–1.52) | 0.013* | |||
Genotype | CC | 146 | 20 | 1 | 82 | 1 | ||||
CT | 272 | 38 | 1.03 (0.51–2.07) | 0.946 | 207 | 1.61 (1.1–2.34) | 0.014* | |||
TT | 120 | 17 | 1.06 (0.59–1.91) | 0.841 | 109 | 1.34 (0.97–1.86) | 0.080 | |||
Dominant | CC | 146 | 20 | 1 | 82 | 1 | ||||
CT-TT | 392 | 55 | 1.05 (0.60–1.83) | 0.863 | 316 | 1.42 (1.04–1.94) | 0.027* | |||
Recessive | CC-CT | 418 | 58 | 1 | 289 | 1 | ||||
TT | 120 | 17 | 0.99 (0.55–1.77) | 0.961 | 109 | 1.31 (0.97–1.78) | 0.078 | |||
Log-additive | 1.01 (0.72–1.44) | 0.936 | 1.27 (1.05–1.53) | 0.015* | ||||||