Fig. 2

CircTP63 downregulation inhibits HCC cell proliferation, migration, invasion, and induces cell apoptosis. a qRT-PCR analysis of circTP63 mRNA expression in SK-hep1 and SNU-387 cells transfected with si-NC, si-circTP63#1 or si-circTP63#2. b, c. CCK8 and colony formation assays were conducted to assess the proliferation of SK-hep1 and SNU-387 cells transfected with si-NC, si-circTP63#1 or si-circTP63#2. d, e Transwell assays were used to assess the migration and invasion abilities of SK-hep1 and SNU-387 transfected with si-NC, si-circTP63#1 or si-circTP63#2. F. Annexin V/PI staining was used to assess the cell apoptosis of SK-hep1 and SNU-387 cells transfected with si-NC, si-circTP63#1 or si-circTP63#2 using flow cytometry. Data are representative of three independent experiments and shown as mean ± SD., **P < 0.01