Fig. 4
From: Prognostic values, ceRNA network, and immune regulation function of SDPR in KRAS-mutant lung cancer
Construction of ceRNA network of SDPR in KRAS-mutant lung adenocarcinoma. a Prediction of upstream transcription factors (TFs) of SDPR in KRAS-mutant lung adenocarcinoma. KRAS-mutant specific TFs were screened out based on GEO dataset (GSE72094), and intersected with SDPR related TFs predicted by online database (Promo or Genecards). b The correlations between SDPR and two predicted TFs, DACH1 and WT-1 based on TCGA dataset (Atlas). c, d Prediction of upstream miRNAs of SDPR in KRAS-mutant lung adenocarcinoma. KRAS-mutant specific miRNAs were screened out based on TCGA dataset (GSE48414), then intersected with SDPR combined miRNAs predicted by miRDB, miranda and targetScan. Five miRNAs finally were screened out and the expression levels in normal tissue and KRAS-mutant lung carcinoma were shown with heat map. f Complementary sequences between hsa-miR-1, DACH1 and SDPR. g Construction of ceRNA network to visualize the regulation models of SDPR, TFs and miRNA in KRAS-mutant lung carcinoma