EGFR genotype | TP and TNa (38 cases with NGS results) | Cobas assay using cfDNA (n = 54) | ddPCR using cfDNA + exoTNA (n = 54) | NGS using cfDNA + exoTNA (n = 38) | |||
---|---|---|---|---|---|---|---|
Mutant type | Wild-type | Mutant type | Wild-type | Mutant type | Wild-type | ||
Mutant type | 43 (32) | 40 | 3 | 41 | 2 | 30 | 2 |
Wild-type | 11 (6) | 0 | 11 | 0 | 11 | 0 | 6 |
Sensitivity,% (95% CI) | 93 (91.7–94.3) | 95.3 (94–96.6) | 93.8 (92.2–95.4) | ||||
Specificity, % (95% CI) | 100 (98.7–101) | 100 (98.7–101) | 100 (98.4–102) | ||||
Accuracy, % (95% CI) | 94.4 (93.1–95.7) | 96.3 (95–97.6) | 94.7 (93.1–96.3) |