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Fig. 3 | Cancer Cell International

Fig. 3

From: IRF4 overexpression promotes the transdifferentiation of tregs into macrophage‐like cells to inhibit the development of colon cancer

Fig. 3

IRF4 overexpression reduced Tregs and M2 macrophages and enhanced M1 macrophages in the colon cancer. SW480 cells were transfected with LV-IRF4, LV-ctrl, LV-sh-IRF4 or LV-shRNA. Then, BALB/c mice were injected with normal or the modified SW480 cells. Normal BALB/c mice served as control. a, b The proportions of Tregs and macrophages in the tumor tissues of mice were detected by flow cytometry. The colon tissues form normal BALB/c mice served as control. ($$P < 0.01, versus Normal; **P < 0.01, versus LV-ctrl; #P < 0.05, ##P < 0.01, versus LV-shRNA)

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Cancer Cell International

ISSN: 1475-2867

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