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Fig. 5 | Cancer Cell International

Fig. 5

From: IRF4 overexpression promotes the transdifferentiation of tregs into macrophage‐like cells to inhibit the development of colon cancer

Fig. 5

IRF4 overexpression repressed cell proliferation, migration and invasion of SW480 and HCT116 cells. Tregs were transfected with LV-IRF4 or LV-ctrl. Normal Tregs served as control. SW480 and HCT116 cells were incubated with the cell culture medium of the normal or modified Tregs. a MTT assay was performed to estimate cell proliferation of SW480 and HCT116 cells. b Wound-healing assay was performed to assess migration of SW480 and HCT116 cells. c Transwell invasion assay was performed to explore invasion of SW480 and HCT116 cells. (*P < 0.05, **P < 0.01, versus LV-ctrl)

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Cancer Cell International

ISSN: 1475-2867

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