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Table 5 Univariate binary logistic regression analysis for the lymph node metastatic risk

From: Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes

Parameter

n

Odds ratio (OR)

95% confidence interval

P value

Gender

 Female

26

0.485

0.151–1.558

0.224

 Male

23

1

  

Age at surgery (years)

 < 65

23

0.727

0.228–2.316

0.590

 ≥ 65

26

1

  

Tumor size (cm3)

 < 33

25

0.788

0.249–2.490

0.684

 ≥ 33

24

   

Localization

 Colon

27

1.203

0.377–3.835

0.755

 Colon sigmoideum/rectum

22

1

  

Tumor type

 Adenocarcinoma

40

0.241

0.052–1.118

0.069

 Mucinous

9

1

  

Tumor grade

 Moderately-well

46

0.293

0.025–3.479

0.331

 Poor

3

1

  

T grade

 T1/2

15

0.063

0.007–0.538

0.011

 T3/4

34

1

  

Lymphovascular invasion

 Absent

36

0.171

0.043–0.683

0.012

 Present

13

1

  

Perineural invasion

 Absent

38

0.264

0.065–1.076

0.063

  Present

11

1

  

Cofilin-1 IHC score

  Low

23

0.238

0.068–0.836

0.025

 High

26

1

  

SSH1 IHC score

  Low

23

0.238

0.068–0.836

0.025

  High

26

1

  

LIMK1 IHC score

 Low

24

0.900

0.285–2.843

0.858

 High

25

1