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Fig. 7 | Cancer Cell International

Fig. 7

From: LncRNA MEG8 promotes NSCLC progression by modulating the miR-15a-5p-miR-15b-5p/PSAT1 axis

Fig. 7

LncRNA MEG8 contributes to tumor growth of NSCLC via miR-15a-5p-miR-15b-5p/PSAT1 axis in vivo. af The effect of lncRNA MEG8-miR-15a-5p/miR-15b-5p axis on tumor growth of NSCLC cells in vivo was analyzed by nude mice tumorigenicity assay. The A549 cells were treated with control shRNA (Ctrl), MEG8 shRNA (shMEG8), or co-treated with MEG8 shRNA (shMEG8), and the inhibitors of miR-15a/b-5p and injected into the nude mice (n = 5). a The average tumor volume was calculated and shown. b The average tumor weight was calculated and shown. c Representative images of dissected tumors from nude mice were presented. d The expression levels of Ki-67 of the tumor tissues were measured by immunohistochemical staining. e The protein expression levels of PSAT1and GAPDH were examined by Western blot analysis in the tumor tissues. f The expression levels of miR-15-5p were tested by qPCR in the tumor tissues. Data are presented as mean ± SD. Statistic significant differences were indicated: *P < 0.05, #P < 0.05

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