Table 2 Comparison of different injection approaches of AAV-based GBM gene therapy
From: Adeno‐associated virus (AAV)-based gene therapy for glioblastoma
Injection approaches | Advantage | Disadvantage | References |
|---|---|---|---|
Intratumoral injection | Overcomes the BBB obstacle | Transduces region limitation, Surgical risk | |
ICVinjection | Good transduction for the brain parenchyma area close to the ventricle | Instability of ICV injection, Only the hemibrain has good transduction | |
Systematic injection | Extensive transduction throughout the brain | Immune barrier, neutralizes antibodies in the blood |