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Fig. 1 | Cancer Cell International

Fig. 1

From: Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention

Fig. 1

A description of both ligand dependent- and independent-AR signaling. Binding of DHT to androgen facilitates its transportation to the nucleus, where it exerts its influence through regulating the transcription of key genes with the help of cofactors and coregulators. In ligand AR-independent activation, AR receptor is activated by either insulin growth factor/epidermal growth factor receptor or by the interleukin-6 signaling which through various cross-talks trigger the expression of desired genes

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Cancer Cell International

ISSN: 1475-2867

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