Fig. 2

Curcumin mediates miRNA regulation in PC. Curcumin treatment modulates several PC pathways by up- or down-regulating the miRNAs associated with several cell pathways. It induces miR-143 expression via FOXD3. MiR-143 inhibits its epigenetic silencer DNMT1 and DNMT2B and also ATG2B and promotes sensitization to radiotherapy. Curcumin also promotes cell cycle arrest by inhibiting B-catenin/cmyc complex via miR-34, sequesters lncRNA-ROR and enhances miR-145 bioavailable, leading to anti-proliferation and invasiveness. Curcumin also inhibits miR-21 and induce cell proliferation suppression by blocking NF-kB pathway and apoptosis via PTEN upregulation