SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer

Dai, Wumin; Feng, Jianguo; Hu, Xiao; Chen, Yongyi; Gu, Qing; Gong, Wangang; Feng, Tingting; Wu, Jie

doi:10.1186/s12935-021-01781-7

Cancer Cell International

Table 1 Correlation analysis between SLC7A7 and relate genes and markers of immune cells in TIMER

From: SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer

Description	Gene markers	LUAD				LUSC
		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P
CD8 + T cell	CD8A	0.52	***	0.402	***	0.723	***	0.683	***
CD8 + T cell	CD8B	0.444	***	0.355	***	0.55	***	0.538	***
T cell (general)	CD3D	0.545	***	0.416	***	0.765	***	0.699	***
	CD3E	0.569	***	0.437	***	0.797	***	0.734	***
	CD2	0.604	***	0.489	***	0.812	***	0.759	**
B cell	CD19	0.313	***	0.13	**	0.539	***	0.389	***
B cell	CD79A	0.299	***	0.125	**	0.586	***	0.449	***
Monocyte	CD86	0.793	***	0.743	***	0.897	***	0.863	***
Monocyte	CSF1R	0.725	***	0.67	***	0.897	***	0.86	***
TAM	CCL2	0.455	***	0.371	***	0.634	***	0.57	***
	CD68	0.797	***	0.758	***	0.795	***	0.75	***
	IL10	0.619	***	0.53	***	0.714	***	0.672	***
M1 Macrophage	NOS2	0.078	0.0817	0.157	***	− 0.013	0.767	0.004	0.926
	IRF5	0.441	***	0.514	***	0.156	**	0.111	*
	PTGS2	− 0.15	***	− 0.13	**	0.044	0.324	− 0.055	0.23
M2 Macrophage	CD163	0.654	***	0.713	***	0.865	***	0.834	***
	VSIG4	0.732	***	0.763	***	0.883	***	0.863	***
	MS4A4A	0.733	***	0.777	***	0.898	***	0.876	***
Neutrophils	CEACAM8	0.266	***	0.226	***	0.129	**	0.113	*
	ITGAM	0.66	***	0.71	***	0.779	***	0.71	***
	CCR7	0.29	***	0.45	***	0.659	***	0.556	***
	KIR2DL1	0.105	*	0.156	**	0.306	**	0.268	***
	KIR2DL3	0.185	***	0.279	***	0.367	**	0.327	***
	KIR2DL4	0.204	***	0.281	***	0.403	***	0.345	***
	KIR3DL1	0.151	***	0.213	***	0.467	***	0.432	***
	KIR3DL2	0.163	***	0.251	***	0.455	***	0.402	***
	KIR3DL3	0.049	0.274	0.075	0.091	0.143	**	0.139	**
	KIR2DS4	0.088	0.050	0.17	***	0.338	***	0.317	**
Dendritic cell	HLA-DPB1	0.602	***	0.521	***	0.893	***	0.858	***
	HLA-DQB1	0.41	***	0.306	***	0.703	***	0.641	***
	HLA-DRA	0.628	***	0.553	***	0.905	***	0.88	***
	HLA-DPA1	0.612	***	0.539	***	0.904	***	0.878	***
	CD1C	0.32	***	0.236	***	0.54	***	0.37	***
	NRP1	0.175	***	0.142	**	0.581	***	0.494	***
	ITGAX	0.694	***	0.615	***	0.767	***	0.677	***
Th1	TBX21	0.5	***	0.368	***	0.695	***	0.615	***
	STAT4	0.455	***	0.325	***	0.704	***	0.612	***
	STAT1	0.465	***	0.377	***	0.529	***	0.493	***
	IFN-γ (IFNG)	0.45	***	0.344	***	0.524	***	0.489	***
	TNF-α (TNF)	0.396	***	0.269	***	0.363	***	0.221	***
Th2	GATA3	0.313	***	0.438	***	0.345	***	0.251	***
	STAT6	0.031	0.488	0.02	0.645	− 0.025	0.638	− 0.055	0.228
	STAT5A	0.564	***	0.65	***	0.645	***	0.549	***
	IL13	0.094	*	0.177	***	0.327	***	0.269	***
Tfh	BCL6	− 0.141	**	− 0.115	**	− 0.177	***	− 0.15	***
Tfh	IL21	0.207	***	0.276	***	0.421	***	0.362	***
Th17	STAT3	− 0.095	*	− 0.092	*	0.162	***	0.089	0.053
Th17	IL17A	0.193	***	0.267	***	0.243	**	0.192	***
Treg	FOXP3	0.421	***	0.537	***	0.742	***	0.654	***
	CCR8	0.458	***	0.578	***	0.753	***	0.687	***
	STAT5B	0.216	***	0.235	***	0.133	**	0.134	**
	TGFβ (TGFB1)	0.304	***	0.394	***	0.215	***	0.076	0.097
T cell exhaustion	PD-1 (PDCD1)	0.356	***	0.485	***	0.69	***	0.612	***
	CTLA4	0.394	***	0.531	***	0.734	***	0.649	***
	LAG3	0.326	***	0.434	***	0.617	***	0.561	***
	TIM-3 (HAVCR2)	0.787	***	0.828	***	0.95	***	0.936	***
	GZMB	0.339	***	0.454	***	0.639	***	0.562	***

p < 0.05 were considered to be statistically significant (*p < 0.05, **p < 0.01, ***p < 0.001)

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