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Table 1 Correlation analysis between SLC7A7 and relate genes and markers of immune cells in TIMER

From: SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer

Description Gene markers LUAD LUSC
None Purity None Purity
Cor P Cor P Cor P Cor P
CD8 + T cell CD8A 0.52 *** 0.402 *** 0.723 *** 0.683 ***
CD8B 0.444 *** 0.355 *** 0.55 *** 0.538 ***
T cell (general) CD3D 0.545 *** 0.416 *** 0.765 *** 0.699 ***
CD3E 0.569 *** 0.437 *** 0.797 *** 0.734 ***
CD2 0.604 *** 0.489 *** 0.812 *** 0.759 **
B cell CD19 0.313 *** 0.13 ** 0.539 *** 0.389 ***
CD79A 0.299 *** 0.125 ** 0.586 *** 0.449 ***
Monocyte CD86 0.793 *** 0.743 *** 0.897 *** 0.863 ***
CSF1R 0.725 *** 0.67 *** 0.897 *** 0.86 ***
TAM CCL2 0.455 *** 0.371 *** 0.634 *** 0.57 ***
CD68 0.797 *** 0.758 *** 0.795 *** 0.75 ***
IL10 0.619 *** 0.53 *** 0.714 *** 0.672 ***
M1 Macrophage NOS2 0.078 0.0817 0.157 *** − 0.013 0.767 0.004 0.926
IRF5 0.441 *** 0.514 *** 0.156 ** 0.111 *
PTGS2 − 0.15 *** − 0.13 ** 0.044 0.324 − 0.055 0.23
M2 Macrophage CD163 0.654 *** 0.713 *** 0.865 *** 0.834 ***
VSIG4 0.732 *** 0.763 *** 0.883 *** 0.863 ***
MS4A4A 0.733 *** 0.777 *** 0.898 *** 0.876 ***
Neutrophils CEACAM8 0.266 *** 0.226 *** 0.129 ** 0.113 *
ITGAM 0.66 *** 0.71 *** 0.779 *** 0.71 ***
CCR7 0.29 *** 0.45 *** 0.659 *** 0.556 ***
KIR2DL1 0.105 * 0.156 ** 0.306 ** 0.268 ***
KIR2DL3 0.185 *** 0.279 *** 0.367 ** 0.327 ***
KIR2DL4 0.204 *** 0.281 *** 0.403 *** 0.345 ***
KIR3DL1 0.151 *** 0.213 *** 0.467 *** 0.432 ***
KIR3DL2 0.163 *** 0.251 *** 0.455 *** 0.402 ***
KIR3DL3 0.049 0.274 0.075 0.091 0.143 ** 0.139 **
KIR2DS4 0.088 0.050 0.17 *** 0.338 *** 0.317 **
Dendritic cell HLA-DPB1 0.602 *** 0.521 *** 0.893 *** 0.858 ***
HLA-DQB1 0.41 *** 0.306 *** 0.703 *** 0.641 ***
HLA-DRA 0.628 *** 0.553 *** 0.905 *** 0.88 ***
HLA-DPA1 0.612 *** 0.539 *** 0.904 *** 0.878 ***
CD1C 0.32 *** 0.236 *** 0.54 *** 0.37 ***
NRP1 0.175 *** 0.142 ** 0.581 *** 0.494 ***
ITGAX 0.694 *** 0.615 *** 0.767 *** 0.677 ***
Th1 TBX21 0.5 *** 0.368 *** 0.695 *** 0.615 ***
STAT4 0.455 *** 0.325 *** 0.704 *** 0.612 ***
STAT1 0.465 *** 0.377 *** 0.529 *** 0.493 ***
IFN-γ (IFNG) 0.45 *** 0.344 *** 0.524 *** 0.489 ***
TNF-α (TNF) 0.396 *** 0.269 *** 0.363 *** 0.221 ***
Th2 GATA3 0.313 *** 0.438 *** 0.345 *** 0.251 ***
STAT6 0.031 0.488 0.02 0.645 − 0.025 0.638 − 0.055 0.228
STAT5A 0.564 *** 0.65 *** 0.645 *** 0.549 ***
IL13 0.094 * 0.177 *** 0.327 *** 0.269 ***
Tfh BCL6 − 0.141 ** − 0.115 ** − 0.177 *** − 0.15 ***
IL21 0.207 *** 0.276 *** 0.421 *** 0.362 ***
Th17 STAT3 − 0.095 * − 0.092 * 0.162 *** 0.089 0.053
IL17A 0.193 *** 0.267 *** 0.243 ** 0.192 ***
Treg FOXP3 0.421 *** 0.537 *** 0.742 *** 0.654 ***
CCR8 0.458 *** 0.578 *** 0.753 *** 0.687 ***
STAT5B 0.216 *** 0.235 *** 0.133 ** 0.134 **
TGFβ (TGFB1) 0.304 *** 0.394 *** 0.215 *** 0.076 0.097
T cell exhaustion PD-1 (PDCD1) 0.356 *** 0.485 *** 0.69 *** 0.612 ***
CTLA4 0.394 *** 0.531 *** 0.734 *** 0.649 ***
LAG3 0.326 *** 0.434 *** 0.617 *** 0.561 ***
TIM-3 (HAVCR2) 0.787 *** 0.828 *** 0.95 *** 0.936 ***
GZMB 0.339 *** 0.454 *** 0.639 *** 0.562 ***
  1. p < 0.05 were considered to be statistically significant (*p < 0.05, **p < 0.01, ***p < 0.001)