Fig. 6

EBV-induced oncogenesis through the Wnt/β-catenin signaling pathway. The binding of Wnt and Frizzled protein will prompt LRP to phosphorylate and recruit protein complexes, and then these protein complexes will dissociate to release stable expression of β-catenin. Free β-catenin binds to TCF to activate the corresponding transcription after entering the nucleus. LMP2A inhibits the expression of GSK-3β through the PI3K/AKT signaling pathway, which interferes with the formation of protein complexes and promotes the accumulation of β-catenin in the nucleus to induce EMT. WTX can inhibit the expression of β-catenin, and LMP1 in transgenic mice will interfere with the inhibitory effect of WTX, resulting in the stable expression of β-catenin and leading to dysplasia