Fig. 4

Decrease of PR55α promotes in vivo cell metastasis and growth. a Xenograft tumor images in nude mice after 4 weeks of growth (n = 5). b Evaluation of tumor weights in PR55α control and knockdown groups. c Representative images of the tumors grown on nude mice with HE, TUNEL and Ki-67 stainings (above). Representative images of HE, Ki-67 and TUNEL staining in tumor xenografts (left). Red signal stains was ki67 positive cells and apoptotic cells. Evaluation of TUNEL positive areas (down right) (P = 0.002) and ki67 expression level (down left) (P = 0.001) was assessed. d Lung metastasis was embedded in paraffin and stained with HE (above). The number of lung metastasis nodules was measured (down) (P = 0.004)