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Fig. 7 | Cancer Cell International

Fig. 7

From: MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1

Fig. 7

Up-regulated miR-1182 and let-7a prevent tumor growth in vivo. a Representative macroscopic picture of transplanted tumors upon treatment with agomir-NC, miR-1182 agomir, let-7a agomir, miR-1182 agomir + let-7a agomir. b The line graph of the tumor volume changes in nude mice. c Tumor weight of nude mice upon treatment with miR-1182 agomir, let-7a agomir, miR-1182 agomir + let-7a agomir. d Representative HE image (×200) of lung metastatic tumor upon treatment with agomir-NC, miR-1182 agomir, let-7a agomir, miR-1182 agomir + let-7a agomir. e Western blot analysis of NUAK1, MMP-2, and MMP-9 expression upon treatment with upon treatment with agomir-NC, miR-1182 agomir, let-7a agomir, miR-1182 agomir + let-7a agomir. p < 0.05 vs. treatment with agomir-NC, # p < 0.05 vs. treatment with miR-1182 agomir or let-7a agomir. The statistical data are measurement data and expressed as mean ± standard deviation. The tumor volume changes were compared with two-way ANOVA and followed by Bonferroni post hoc test

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