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Table 1 The roles of IGF2BP2 in various metabolic diseases and the associations between the expression of IGF2BP2 SNPs and the development several metabolic diseases as well as cancer in different populations

From: The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

Metabolic diseases

SNPs

Population

Biological functions

Refs.

Diabetes

rs4402960

Chinese Han population

Protected against T2D, enhanced the therapeutic efficacy of repaglinide, and reduced the effect of pioglitazone on PPG, TG, and HDL-C

[27,28,29,30,31, 41, 42]

Japanese population

\

[32]

Asians

\

[27, 33]

Iceland’s population

Decreased fasting insulin levels, impaired β-cell function

[34]

Greek-Cypriot population

\

[35]

Czech population

\

[26]

Germany population

\

[33, 36]

Lebanese Arabs

\

[37]

Arab population

\

[38]

Moroccan population

\

[38]

Tunisian population

\

[39]

India’s population

\

[40]

\

Predict the occurrence and diagnosis of GDM

[43]

Poland population

Influenced the length of gestation and the Apgar scores of newborns

[44]

rs1470579

Chinese Han population

Reduced the therapeutic efficacy of repaglinide and the effect of pioglitazone on PPG, TG, and HDL-C

[29, 30, 42]

Lebanese population

\

[46]

Iranian population

\

[47]

rs11705701

Mexican American population

Affected insulin resistance

[53]

Russian population

Contributed to T2D risk, decreased levels of p58 and increased levels of p66 of the IGF2BP2 in adipose tissue of non-obese individuals

[51]

Poland population

Influenced the length of gestation and the Apgar scores of newborns

[44]

\

Associated with prediabetes

[54]

rs9826022

\

\

[48]

rs11927381

Chinese Han population

\

[55]

rs7640539

[55]

rs6777038

\

Associated with GADA negative diabetes

[56]

rs16860234

rs7651090

Nonalcoholic steatohepatitis

\

\

Increased the ratio of C18:C16 and the expression of ELOVL6

[63]

\

\

Promoted the de-differentiated cells toward steatohepatitis-associated cirrhosis development via accelerating DR

[64]

Obesity

\

\

IGF2BP2 deficiency induced the resistance to diet-induced obesity and fatty liver, and showed great glucose tolerance and insulin sensitivity

[12]

Fatty liver

\

\

IGF2BP2 knockout impaired fatty acid oxidation and promoted modest diet-induced fatty liver

[13]

  1. “\”: indicates not mentioned
  2. SNP single nucleotide polymorphisms, T2D type 2 diabetes, PPG postprandial plasma glucose, TG triglycerides, HDL-C high-density lipoprotein cholesterol, GDM gestational diabetes mellitus, GADA glutamic acid decarboxylase antibodies, ELOVL6 fatty acid elongase 6, DR ductular reaction