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Table 1 The roles of IGF2BP2 in various metabolic diseases and the associations between the expression of IGF2BP2 SNPs and the development several metabolic diseases as well as cancer in different populations

From: The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

Metabolic diseases SNPs Population Biological functions Refs.
Diabetes rs4402960 Chinese Han population Protected against T2D, enhanced the therapeutic efficacy of repaglinide, and reduced the effect of pioglitazone on PPG, TG, and HDL-C [27,28,29,30,31, 41, 42]
Japanese population \ [32]
Asians \ [27, 33]
Iceland’s population Decreased fasting insulin levels, impaired β-cell function [34]
Greek-Cypriot population \ [35]
Czech population \ [26]
Germany population \ [33, 36]
Lebanese Arabs \ [37]
Arab population \ [38]
Moroccan population \ [38]
Tunisian population \ [39]
India’s population \ [40]
\ Predict the occurrence and diagnosis of GDM [43]
Poland population Influenced the length of gestation and the Apgar scores of newborns [44]
rs1470579 Chinese Han population Reduced the therapeutic efficacy of repaglinide and the effect of pioglitazone on PPG, TG, and HDL-C [29, 30, 42]
Lebanese population \ [46]
Iranian population \ [47]
rs11705701 Mexican American population Affected insulin resistance [53]
Russian population Contributed to T2D risk, decreased levels of p58 and increased levels of p66 of the IGF2BP2 in adipose tissue of non-obese individuals [51]
Poland population Influenced the length of gestation and the Apgar scores of newborns [44]
\ Associated with prediabetes [54]
rs9826022 \ \ [48]
rs11927381 Chinese Han population \ [55]
rs7640539 [55]
rs6777038 \ Associated with GADA negative diabetes [56]
rs16860234
rs7651090
Nonalcoholic steatohepatitis \ \ Increased the ratio of C18:C16 and the expression of ELOVL6 [63]
\ \ Promoted the de-differentiated cells toward steatohepatitis-associated cirrhosis development via accelerating DR [64]
Obesity \ \ IGF2BP2 deficiency induced the resistance to diet-induced obesity and fatty liver, and showed great glucose tolerance and insulin sensitivity [12]
Fatty liver \ \ IGF2BP2 knockout impaired fatty acid oxidation and promoted modest diet-induced fatty liver [13]
  1. “\”: indicates not mentioned
  2. SNP single nucleotide polymorphisms, T2D type 2 diabetes, PPG postprandial plasma glucose, TG triglycerides, HDL-C high-density lipoprotein cholesterol, GDM gestational diabetes mellitus, GADA glutamic acid decarboxylase antibodies, ELOVL6 fatty acid elongase 6, DR ductular reaction
\