From: The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
Metabolic diseases | SNPs | Population | Biological functions | Refs. |
---|---|---|---|---|
Diabetes | rs4402960 | Chinese Han population | Protected against T2D, enhanced the therapeutic efficacy of repaglinide, and reduced the effect of pioglitazone on PPG, TG, and HDL-C | |
Japanese population | \ | [32] | ||
Asians | \ | |||
Iceland’s population | Decreased fasting insulin levels, impaired β-cell function | [34] | ||
Greek-Cypriot population | \ | [35] | ||
Czech population | \ | [26] | ||
Germany population | \ | |||
Lebanese Arabs | \ | [37] | ||
Arab population | \ | [38] | ||
Moroccan population | \ | [38] | ||
Tunisian population | \ | [39] | ||
India’s population | \ | [40] | ||
\ | Predict the occurrence and diagnosis of GDM | [43] | ||
Poland population | Influenced the length of gestation and the Apgar scores of newborns | [44] | ||
rs1470579 | Chinese Han population | Reduced the therapeutic efficacy of repaglinide and the effect of pioglitazone on PPG, TG, and HDL-C | ||
Lebanese population | \ | [46] | ||
Iranian population | \ | [47] | ||
rs11705701 | Mexican American population | Affected insulin resistance | [53] | |
Russian population | Contributed to T2D risk, decreased levels of p58 and increased levels of p66 of the IGF2BP2 in adipose tissue of non-obese individuals | [51] | ||
Poland population | Influenced the length of gestation and the Apgar scores of newborns | [44] | ||
\ | Associated with prediabetes | [54] | ||
rs9826022 | \ | \ | [48] | |
rs11927381 | Chinese Han population | \ | [55] | |
rs7640539 | [55] | |||
rs6777038 | \ | Associated with GADA negative diabetes | [56] | |
rs16860234 | ||||
rs7651090 | ||||
Nonalcoholic steatohepatitis | \ | \ | Increased the ratio of C18:C16 and the expression of ELOVL6 | [63] |
\ | \ | Promoted the de-differentiated cells toward steatohepatitis-associated cirrhosis development via accelerating DR | [64] | |
Obesity | \ | \ | IGF2BP2 deficiency induced the resistance to diet-induced obesity and fatty liver, and showed great glucose tolerance and insulin sensitivity | [12] |
Fatty liver | \ | \ | IGF2BP2 knockout impaired fatty acid oxidation and promoted modest diet-induced fatty liver | [13] |